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Brain pathology after mild traumatic brain injury: An exploratory study by repeated magnetic resonance examination
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Rehabilitation Medicine. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centre for Research and Development, Gävleborg.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Radiology.
Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Division of Visual Information and Interaction. Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Computerized Image Analysis and Human-Computer Interaction.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Rehabilitation Medicine.
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2013 (English)In: Journal of Rehabilitation Medicine, ISSN 1650-1977, E-ISSN 1651-2081, Vol. 45, no 8, 721-728 p.Article in journal (Refereed) Published
Abstract [en]

Objective:

To explore brain pathology after mild traumatic brain injury by repeated magnetic resonance examination.

Design:

A prospective follow-up study.

Subjects:

Nineteen patients with mild traumatic brain injury presenting with Glasgow Coma Scale (GCS) 14-15.

Methods:

The patients were examined on day 2 or 3 and 3-7 months after the injury. The magnetic resonance protocol comprised conventional T1- and T2-weighted sequences including fluid attenuated inversion recovery (FLAIR), two susceptibility-weighted sequences to reveal haemorrhages, and diffusion-weighted sequences. Computer-aided volume comparison was performed. Clinical outcome was assessed by the Rivermead Post-Concussion Symptoms Questionnaire (RPQ), Hospital Anxiety and Depression Scale (HADS) and Glasgow Outcome Scale Extended (GOSE).

Results:

At follow-up, 7 patients (37%) reported ≥  3 symptoms in RPQ, 5 reported some anxiety and 1 reported mild depression. Fifteen patients reported upper level of good recovery and 4 patients lower level of good recovery (GOSE 8 and 7, respectively). Magnetic resonance pathology was found in 1 patient at the first examination, but 4 patients (21%) showed volume loss at the second examination, at which 3 of them reported < 3 symptoms and 1 ≥ 3 symptoms, all exhibiting GOSE scores of 8.

Conclusion:

Loss of brain volume, demonstrated by computer-aided magnetic resonance imaging volumetry, may be a feasible marker of brain pathology after mild traumatic brain injury.

Place, publisher, year, edition, pages
2013. Vol. 45, no 8, 721-728 p.
National Category
Radiology, Nuclear Medicine and Medical Imaging Medical Image Processing
Identifiers
URN: urn:nbn:se:uu:diva-207659DOI: 10.2340/16501977-1169ISI: 000326357500005PubMedID: 24002306OAI: oai:DiVA.org:uu-207659DiVA: diva2:648983
Available from: 2013-09-17 Created: 2013-09-17 Last updated: 2017-12-06Bibliographically approved

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Lannsjö, MarianneRaininko, Raili

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Rehabilitation MedicineCentre for Research and Development, GävleborgRadiologyDivision of Visual Information and InteractionComputerized Image Analysis and Human-Computer Interaction
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Journal of Rehabilitation Medicine
Radiology, Nuclear Medicine and Medical ImagingMedical Image Processing

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