Brain pathology after mild traumatic brain injury: An exploratory study by repeated magnetic resonance examination
2013 (English)In: Journal of Rehabilitation Medicine, ISSN 1650-1977, Vol. 45, no 8, 721-728 p.Article in journal (Refereed) Published
To explore brain pathology after mild traumatic brain injury by repeated magnetic resonance examination.
A prospective follow-up study.
Nineteen patients with mild traumatic brain injury presenting with Glasgow Coma Scale (GCS) 14-15.
The patients were examined on day 2 or 3 and 3-7 months after the injury. The magnetic resonance protocol comprised conventional T1- and T2-weighted sequences including fluid attenuated inversion recovery (FLAIR), two susceptibility-weighted sequences to reveal haemorrhages, and diffusion-weighted sequences. Computer-aided volume comparison was performed. Clinical outcome was assessed by the Rivermead Post-Concussion Symptoms Questionnaire (RPQ), Hospital Anxiety and Depression Scale (HADS) and Glasgow Outcome Scale Extended (GOSE).
At follow-up, 7 patients (37%) reported ≥ 3 symptoms in RPQ, 5 reported some anxiety and 1 reported mild depression. Fifteen patients reported upper level of good recovery and 4 patients lower level of good recovery (GOSE 8 and 7, respectively). Magnetic resonance pathology was found in 1 patient at the first examination, but 4 patients (21%) showed volume loss at the second examination, at which 3 of them reported < 3 symptoms and 1 ≥ 3 symptoms, all exhibiting GOSE scores of 8.
Loss of brain volume, demonstrated by computer-aided magnetic resonance imaging volumetry, may be a feasible marker of brain pathology after mild traumatic brain injury.
Place, publisher, year, edition, pages
2013. Vol. 45, no 8, 721-728 p.
Radiology, Nuclear Medicine and Medical Imaging Medical Image Processing
IdentifiersURN: urn:nbn:se:uu:diva-207659DOI: 10.2340/16501977-1169ISI: 000326357500005PubMedID: 24002306OAI: oai:DiVA.org:uu-207659DiVA: diva2:648983