A comparison between two powder compaction parameters of plasticity: The effective medium A parameter and the Heckel 1/K parameter
2013 (English)In: International Journal of Pharmaceutics, ISSN 0378-5173, E-ISSN 1873-3476, Vol. 453, no 2, 295-299 p.Article in journal (Refereed) Published
The purpose of the research was to introduce a procedure to derive a powder compression parameter (EM A) representing particle yield stress using an effective medium equation and to compare the EM A parameter with the Heckel compression parameter (1/K). 16 pharmaceutical powders, including drugs and excipients, were compressed in a materials testing instrument and powder compression profiles were derived using the EM and Heckel equations. The compression profiles thus obtained could be sub-divided into regions among which one region was approximately linear and from this region, the compression parameters EM A and 1/K were calculated. A linear relationship between the EM A parameter and the 1/K parameter was obtained with a strong correlation. The slope of the plot was close to 1 (0.84) and the intercept of the plot was small in comparison to the range of parameter values obtained. The relationship between the theoretical EM A parameter and the 1/K parameter supports the interpretation of the empirical Heckel parameter as being a measure of yield stress. It is concluded that the combination of Heckel and EM equations represents a suitable procedure to derive a value of particle plasticity from powder compression data.
Place, publisher, year, edition, pages
2013. Vol. 453, no 2, 295-299 p.
Powder compression, Compression parameter, Yield stress, Effective medium equation, Heckel equation
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-208359DOI: 10.1016/j.ijpharm.2013.06.040ISI: 000323015800001OAI: oai:DiVA.org:uu-208359DiVA: diva2:652422