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Coordination of TGF-beta Signaling by Ubiquitylation
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Ludwig Institute for Cancer Research. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Uppsala University, Science for Life Laboratory, SciLifeLab.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Ludwig Institute for Cancer Research. Uppsala University, Science for Life Laboratory, SciLifeLab.
2013 (English)In: Molecular Cell, ISSN 1097-2765, E-ISSN 1097-4164, Vol. 51, no 5, 555-556 p.Article in journal, Editorial material (Other academic) Published
Abstract [en]

In this issue, Zhang et al. (2013) demonstrate that the ubiquitin ligase TRAF4 associates with the TGF-β receptors, rescuing them from degradation and ubiquitylating TAK1 to activate non-Smad signaling, which together promote metastasis of breast cancer cells.

Place, publisher, year, edition, pages
2013. Vol. 51, no 5, 555-556 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-208561DOI: 10.1016/j.molcel.2013.08.034ISI: 000330189500002PubMedID: 24034692OAI: oai:DiVA.org:uu-208561DiVA: diva2:653191
Note

Hänvisar till:

Long Zhang, Fangfang Zhou, Amaya García de Vinuesa, Esther M. de Kruijf, Wilma E. Mesker, Li Hui, Yvette Drabsch, Yihao Li, Andreas Bauer, Adrien Rousseau, Kelly-Ann Sheppard, Craig Mickanin, Peter J.K. Kuppen, Chris X. Lu, Peter ten DijkeTRAF4 Promotes TGF-β Receptor Signaling and Drives Breast Cancer MetastasisMolecular Cell, Volume 51, Issue 5, 12 September 2013, Pages 559-572

http://dx.doi.org/10.1016/j.molcel.2013.07.014

Available from: 2013-10-03 Created: 2013-10-03 Last updated: 2017-12-06Bibliographically approved

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Moustakas, AristidisHeldin, Carl-Henrik

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Ludwig Institute for Cancer ResearchDepartment of Medical Biochemistry and MicrobiologyScience for Life Laboratory, SciLifeLab
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