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The recognition and cleavage of RNA in the antisense oligo-RNA hybrid duplexes by RNase H
Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Faculty of Science and Technology, Biology, Department of Bioorganic Chemistry.
2001 (English)In: TETRAHEDRON LETTERS, ISSN 0040-4039, Vol. 42, no 3, 489-491 p.Article in journal (Refereed) Published
Abstract [en]

The different extent of the target RNA cleavage at t(99.9%) by RNase H in the AON-RNA duplexes, at the RNA saturation condition by antisense oligo, is due to different recognition and catalytic properties of RNase H toward the hybrids owing to different s

Place, publisher, year, edition, pages
PERGAMON-ELSEVIER SCIENCE LTD , 2001. Vol. 42, no 3, 489-491 p.
Keyword [en]
ALKYLATING OLIGONUCLEOTIDE DERIVATIVES; CHOLESTEROL
Identifiers
URN: urn:nbn:se:uu:diva-37619OAI: oai:DiVA.org:uu-37619DiVA: diva2:65518
Note
Addresses: Chattopadhyaya J, Univ Uppsala, Ctr Biomed, Dept Bioorgan Chem, Box 581, S-75123 Uppsala, Sweden. Univ Uppsala, Ctr Biomed, Dept Bioorgan Chem, S-75123 Uppsala, Sweden.Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2011-01-14

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