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Water-soluble organotellurium compounds inhibit thioredoxin reductase and the growth of human cancer cells
Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
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2000 (English)In: ANTI-CANCER DRUG DESIGN, ISSN 0266-9536, Vol. 15, no 5, 323-330 p.Article in journal (Refereed) Published
Abstract [en]

The thioredoxin system (NADPH, thioredoxin reductase/ thioredoxin) is important for cancer cell growth and inhibition of apoptosis and presents an attractive target for anticancer drug development. Thioredoxin reductase is a selenocysteine-containing flav

Place, publisher, year, edition, pages
OXFORD UNIV PRESS , 2000. Vol. 15, no 5, 323-330 p.
Keyword [en]
thioredoxin reductase; water-soluble organotellurium compounds; antitumor activity; DNA-BINDING ACTIVITY; REDOX REGULATION; MESSENGER-RNA; HUMAN TUMORS; EXPRESSION; SELENOCYSTEINE; CLONING; PURIFICATION; COEXPRESSION; SEQUENCE
Identifiers
URN: urn:nbn:se:uu:diva-37627OAI: oai:DiVA.org:uu-37627DiVA: diva2:65526
Note
Addresses: Engman L, Univ Uppsala, Inst Chem, Dept Organ Chem, Box 531, S-75121 Uppsala, Sweden. Univ Uppsala, Inst Chem, Dept Organ Chem, S-75121 Uppsala, Sweden. Univ Arizona, Arizona Canc Ctr, Tucson, AZ 85724 USA.Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2011-01-14

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