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Conformation-specific cleavage of antisense oligonucleotide-RNA duplexes by RNase H
Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Faculty of Science and Technology, Biology, Department of Bioorganic Chemistry.
2001 (English)In: JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2, ISSN 1472-779X, no 3, 402-408 p.Article in journal (Refereed) Published
Abstract [en]

The North-form (3'-endo) constrained 1-(1',3'-O-anhydro-beta -D-psicofuranosyl)thymine block, T, was systematically incorporated at various sites, one at a time, into a set of four antisense oligonucleotides (AONs). The hybrids of these AONs with a matche

Place, publisher, year, edition, pages
ROYAL SOC CHEMISTRY , 2001. no 3, 402-408 p.
Keyword [en]
LOCKED NUCLEIC-ACIDS; CARBOCYCLIC THYMIDINE; BIOLOGICAL-ACTIVITY; NUCLEOSIDES; ANALOGS; OLIGODEOXYNUCLEOTIDES; STABILITY; LNA; DNA; 3'-O;4'-C-METHYLENERIBONUCLEOSIDES
Identifiers
URN: urn:nbn:se:uu:diva-37663OAI: oai:DiVA.org:uu-37663DiVA: diva2:65562
Note
Addresses: Chattopadhyaya J, Univ Uppsala, Ctr Biomed, Dept Bioorgan Chem, Box 581, S-75123 Uppsala, Sweden. Univ Uppsala, Ctr Biomed, Dept Bioorgan Chem, S-75123 Uppsala, Sweden.Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2011-01-14

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