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The 3 '-modified antisense oligos promote faster hydrolysis of the target RNA by RNase H than the natural counterpart
Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Faculty of Science and Technology, Biology, Department of Bioorganic Chemistry.
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2001 (English)In: TETRAHEDRON, ISSN 0040-4020, Vol. 57, no 3, 593-606 p.Article in journal (Refereed) Published
Abstract [en]

We have examined the antisense potency of the hybrid duplexes of fully-matched 3'-, 5' and interior-chromophore tethered antisense oligos (AON) and three target RNAs (11mer and two 17mers) against RNase H, and found them to be better substrates compared t

Place, publisher, year, edition, pages
PERGAMON-ELSEVIER SCIENCE LTD , 2001. Vol. 57, no 3, 593-606 p.
Keyword [en]
antisense; oligos; RNAs; ALKYLATING OLIGONUCLEOTIDE DERIVATIVES; DNA-RNA; GENE-EXPRESSION; OLIGODEOXYNUCLEOTIDES; STABILITY; INHIBITION; DUPLEXES; CHOLESTEROL; CLEAVAGE; HAIRPIN
Identifiers
URN: urn:nbn:se:uu:diva-37674OAI: oai:DiVA.org:uu-37674DiVA: diva2:65573
Note
Addresses: Chattopadhyaya J, Univ Uppsala, Ctr Biomed, Dept Bioorgan Chem, Box 581, S-75123 Uppsala, Sweden. Univ Uppsala, Ctr Biomed, Dept Bioorgan Chem, S-75123 Uppsala, Sweden.Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2011-01-14

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