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A critical survey of the structure-function of the antisense oligo/RNA heteroduplex as substrate for RNase H
Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Faculty of Science and Technology, Biology, Department of Bioorganic Chemistry.
2001 (English)In: JOURNAL OF BIOCHEMICAL AND BIOPHYSICAL METHODS, Vol. 48, no 3, 189-208 p.Article, book review (Other scientific) Published
Abstract [en]

The aim of this review is to draw a correlation between the structure of the DNA/RNA hybrid and its properties as a substrate for the RNase H, as well as to point the crucial structural requirements for the modified AONs to preserve their RNase H potency.

Place, publisher, year, edition, pages
ELSEVIER SCIENCE BV , 2001. Vol. 48, no 3, 189-208 p.
Keyword [en]
structure; DNA/RNA hybrid; AONs; RNase H; COLI RIBONUCLEASE HI; ALKYLATING OLIGONUCLEOTIDE DERIVATIVES; ARABINONUCLEIC ACIDS ANA; LOCKED NUCLEIC-ACID; ESCHERICHIA-COLI; DNA-REPLICATION; HYBRID DUPLEXES; MESSENGER-RNA; THERAPEUTIC AGENTS; COMPLEMENTARY RNA
Identifiers
URN: urn:nbn:se:uu:diva-37675OAI: oai:DiVA.org:uu-37675DiVA: diva2:65574
Note
Addresses: Chattopadhyaya J, Univ Uppsala, Ctr Biomed, Dept Bioorgan Chem, Box 581, S-75123 Uppsala, Sweden. Univ Uppsala, Ctr Biomed, Dept Bioorgan Chem, S-75123 Uppsala, Sweden.Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2011-01-14

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