uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Peptide interactions with bacterial lipopolysaccharides
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacy.
2013 (English)In: Current Opinion in Colloid & Interface Science, ISSN 1359-0294, Vol. 18, no 5, 381-392 p.Article, review/survey (Refereed) Published
Abstract [en]

Peptide and protein interactions with (lipo)polysaccharides are important in various biological contexts, including lipoprotein deposition at proteoglycan-covered endothelial surfaces in atherosclerosis, lectin functionality, and the interaction of antimicrobial and anti-inflammatory peptides and proteins with (lipo)polysaccharides. The latter of these areas, which is the topic of this review, has attracted considerable interest during the last few years, since antimicrobial peptides may offer novel therapeutic opportunities in an era of growing problems with antibiotic resistance, and persisting problems with both acute and chronic inflammation. In the present overview, physicochemical factors affecting peptide interactions with bacterial (lipo)polysaccharides are discussed, both in solution and at membrane interfaces. In doing so, an attempt is made to illustrate how physicochemical factors affect the antimicrobial and anti-endotoxic functionality of such peptides, and how knowledge on this can be translated into therapeutic opportunities, e.g., in sepsis.

Place, publisher, year, edition, pages
2013. Vol. 18, no 5, 381-392 p.
Keyword [en]
Anti-endotoxic, Antimicrobial, Lipid A, Lipopolysaccharide, Peptide
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-209222DOI: 10.1016/j.cocis.2013.06.003ISI: 000324356400002OAI: oai:DiVA.org:uu-209222DiVA: diva2:656390
Available from: 2013-10-15 Created: 2013-10-15 Last updated: 2013-10-15Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Malmsten, Martin
By organisation
Department of Pharmacy
In the same journal
Current Opinion in Colloid & Interface Science
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 165 hits
ReferencesLink to record
Permanent link

Direct link