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Peptide interactions with bacterial lipopolysaccharides
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacy.
2013 (English)In: Current Opinion in Colloid & Interface Science, ISSN 1359-0294, E-ISSN 1879-0399, Vol. 18, no 5, 381-392 p.Article, review/survey (Refereed) Published
Abstract [en]

Peptide and protein interactions with (lipo)polysaccharides are important in various biological contexts, including lipoprotein deposition at proteoglycan-covered endothelial surfaces in atherosclerosis, lectin functionality, and the interaction of antimicrobial and anti-inflammatory peptides and proteins with (lipo)polysaccharides. The latter of these areas, which is the topic of this review, has attracted considerable interest during the last few years, since antimicrobial peptides may offer novel therapeutic opportunities in an era of growing problems with antibiotic resistance, and persisting problems with both acute and chronic inflammation. In the present overview, physicochemical factors affecting peptide interactions with bacterial (lipo)polysaccharides are discussed, both in solution and at membrane interfaces. In doing so, an attempt is made to illustrate how physicochemical factors affect the antimicrobial and anti-endotoxic functionality of such peptides, and how knowledge on this can be translated into therapeutic opportunities, e.g., in sepsis.

Place, publisher, year, edition, pages
2013. Vol. 18, no 5, 381-392 p.
Keyword [en]
Anti-endotoxic, Antimicrobial, Lipid A, Lipopolysaccharide, Peptide
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-209222DOI: 10.1016/j.cocis.2013.06.003ISI: 000324356400002OAI: oai:DiVA.org:uu-209222DiVA: diva2:656390
Available from: 2013-10-15 Created: 2013-10-15 Last updated: 2017-12-06Bibliographically approved

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Malmsten, Martin

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