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IVF and breast cancer: a systematic review and meta-analysis
Department of Hygiene, Epidemiology and Medical Statistics, Medical School, University of Athens, Greece.
Department of Hygiene, Epidemiology and Medical Statistics, Medical School, University of Athens, Greece.
Department of Hygiene, Epidemiology and Medical Statistics, Medical School, University of Athens, Greece.
Department of Hygiene, Epidemiology and Medical Statistics, Medical School, University of Athens, Greece.
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2014 (English)In: Human Reproduction Update, ISSN 1355-4786, E-ISSN 1460-2369, Vol. 20, no 1, 106-123 p.Article, review/survey (Refereed) Published
Abstract [en]

BACKGROUND

The effects of controlled ovarian hyperstimulation (COH) for IVF in terms of breast cancer risk remain controversial, despite the hormone-dependent nature of the latter.

METHODS

Eligible studies up to 15 February 2013 were identified and pooled effect estimates for relative risk (RR) were calculated separately for the investigations using the general population and those using infertile women, as a reference group. Fixed- or random-effects models were implemented and subgroup analyses were performed, as appropriate.

RESULTS

Eight cohort studies were synthesized, yielding a total cohort size of 1 554 332 women among whom 14 961 incident breast cancer cases occurred, encompassing 576 incident breast cancer cases among women exposed to IVF. No significant association between IVF and breast cancer was observed either in the group of studies treating the general population (RR = 0.91, 95% confidence interval (CI): 0.74–1.11) or infertile women (RR = 1.02, 95% CI: 0.88–1.18), as a reference group. Of note were the marginal associations, protective for pregnant and/or parous women after IVF (pooled effect estimate = 0.86, 95% CI: 0.73–1.01) and adverse for women <30 years at first IVF treatment (pooled effect estimate = 1.64, 95% CI: 0.96–2.80).

CONCLUSIONS

At present, COH for IVF does not seem to impart increased breast cancer risk. Longer follow-up periods, comparisons versus infertile women, subgroup analyses aiming to trace vulnerable subgroups, adjustment for various confounders and larger informative data sets are needed before conclusive statements for the safety of the procedure are reached.

Place, publisher, year, edition, pages
2014. Vol. 20, no 1, 106-123 p.
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Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-209526DOI: 10.1093/humupd/dmt034ISI: 000328363200007PubMedID: 23884897OAI: oai:DiVA.org:uu-209526DiVA: diva2:658340
Available from: 2013-10-21 Created: 2013-10-21 Last updated: 2017-12-06Bibliographically approved

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Skalkidou, Alkistis

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