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Active site serine promotes stabilization of the reactive glutathione thiolate in rat glutathione transferase T2-2 - Evidence against proposed sulfatase activity of the corresponding human enzyme
Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Biochemistry.
2000 (English)In: JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, Vol. 275, no 12, 8618-8624 p.Article in journal (Refereed) Published
Abstract [en]

Ser(11) in rat glutathione transferase T2-2 is important for stabilization of the reactive enzyme-bound glutathione thiolate in the reaction with 1-menaphthyl sulfate. The S11A mutation increased the pK(a) value for the pH dependence of the rate constant

Place, publisher, year, edition, pages
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC , 2000. Vol. 275, no 12, 8618-8624 p.
Keyword [en]
CATALYTIC ACTIVITY; THETA; DISCRIMINATION; DESIGN; ESTERS; ACIDS
Identifiers
URN: urn:nbn:se:uu:diva-37981OAI: oai:DiVA.org:uu-37981DiVA: diva2:65880
Note
Addresses: Mannervik B, Univ Uppsala, Ctr Biomed, Dept Biochem, Box 576, S-75123 Uppsala, Sweden. Univ Uppsala, Ctr Biomed, Dept Biochem, S-75123 Uppsala, Sweden.Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2011-01-14

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