Ser11 plays several roles in the catalytic mechanism of rat glutathione transferase T2-2
2001 (English)In: CHEMICO-BIOLOGICAL INTERACTIONS, ISSN 0009-2797, Vol. 133, no 1-3, 178-181 p.Article in journal (Refereed) Published
Ser11 in rat glutathione transferase T2-2 promotes several steps in the catalyzed reaction pathway of the enzyme. First, the residue lowers the pK(a) value of the enzyme-bound glutathione thiol by 2.2 pH units, from 7.9 to 5.7. Secondly, the presence of S
Place, publisher, year, edition, pages
ELSEVIER SCI IRELAND LTD , 2001. Vol. 133, no 1-3, 178-181 p.
pre-steady-state kinetics; theta-class glutathione transferase; catalysis; product release
IdentifiersURN: urn:nbn:se:uu:diva-38019OAI: oai:DiVA.org:uu-38019DiVA: diva2:65918
Addresses: Mannervik B, Uppsala Univ, Dept Biochem, Biomed Ctr, Box 576, SE-75123 Uppsala, Sweden. Uppsala Univ, Dept Biochem, Biomed Ctr, SE-75123 Uppsala, Sweden.2008-10-172008-10-172011-01-14