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Muscle atrophy in aging and chronic diseases: is it sarcopenia or cachexia?
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism.
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2013 (English)In: INTERNAL AND EMERGENCY MEDICINE, ISSN 1828-0447, Vol. 8, no 7, 553-560 p.Article, review/survey (Refereed) Published
Abstract [en]

Cachexia and sarcopenia present several analogies in both the pathogenic mechanisms and the clinical picture. The loss of muscle mass and strength is a hallmark of these two clinical conditions. Although frequently overlapping and often indistinguishable, especially in old individuals, these two conditions should be considered distinct clinical entities. A prompt and accurate patient evaluation, guiding the physician through a proper differential diagnostic procedure and providing the best therapeutic options, is recommended. Given the several commonalities between cachexia and sarcopenia, it is likely that the therapeutic approaches may prove effective in both conditions. This review focuses on the most recent available literature and aims at providing physicians with the correct tools that are available to aid in diagnosing these two different entities that often clinically overlap. Currently available or proposed therapeutic strategies for pre-cachexia, cachexia and sarcopenia are also briefly described.

Place, publisher, year, edition, pages
2013. Vol. 8, no 7, 553-560 p.
Keyword [en]
Cachexia, Pre-cachexia, Sarcopenia, Muscle, Aging, Comorbidity
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-209702DOI: 10.1007/s11739-012-0807-8ISI: 000324615900002OAI: oai:DiVA.org:uu-209702DiVA: diva2:659195
Available from: 2013-10-24 Created: 2013-10-24 Last updated: 2013-10-24Bibliographically approved

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Cederholm, Tommy
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