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Changes in matrix proteoglycans induced by insulin and fatty acids in hepatic cells may contribute to dyslipidemia of insulin resistance
Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Biochemistry.
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2001 (English)In: DIABETES, ISSN 0012-1797, Vol. 50, no 9, 2126-2132 p.Article in journal (Refereed) Published
Abstract [en]

Insulin resistance and type 2 diabetes are associated with elevated circulating levels of insulin, nonesterified fatty acids (NEFAs), and lipoprotein remnants. Extracellular matrix proteoglycan (PG) alterations are also common in macro- and microvascular

Place, publisher, year, edition, pages
AMER DIABETES ASSOC , 2001. Vol. 50, no 9, 2126-2132 p.
Keyword [en]
SMOOTH-MUSCLE CELLS; PROTEIN-KINASE-C; CULTURED ENDOTHELIAL MONOLAYERS; HEPARAN-SULFATE PROTEOGLYCANS; LOW-DENSITY LIPOPROTEINS; LINOLEIC-ACID; APOLIPOPROTEIN-E; BINDING; EXPOSURE; ATHEROGENESIS
Identifiers
URN: urn:nbn:se:uu:diva-38030OAI: oai:DiVA.org:uu-38030DiVA: diva2:65929
Note
Addresses: Camejo G, AstraZeneca Preclin Res Labs, S-41345 Molndal, Sweden. AstraZeneca Preclin Res Labs, S-41345 Molndal, Sweden. Univ Gothenburg, Sahlgrens Univ Hosp, Wallenberg Lab Cardiovasc Res, Gothenburg, Sweden. Univ Coll Boras, Sch Hlth Sci, BoraAvailable from: 2008-10-17 Created: 2008-10-17 Last updated: 2011-01-14

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