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Chromatographic retention of drug molecules on immobilised liposomes prepared from egg phospholipids and from chemically pure phospholipids
Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Biochemistry.
2001 (English)In: EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, ISSN 0928-0987, Vol. 12, no 4, 427-439 p.Article in journal (Refereed) Published
Abstract [en]

The partitioning of a chemically diverse set of drugs into liposomes was studied by immobilised liposome chromatography (ILC). For this purpose liposomes composed of (i) purified egg phospholipids (EPL), (ii) synthetic phosphatidylcholine (PC), (iii) PC-s

Place, publisher, year, edition, pages
ELSEVIER SCIENCE BV , 2001. Vol. 12, no 4, 427-439 p.
Keyword [en]
OCTANOL-WATER PARTITION; GEL BEADS; LIPID BILAYERS; UNILAMELLAR LIPOSOMES; SURFACE PROPERTIES; COEFFICIENTS; PERMEABILITY; IMMOBILIZATION; ABSORPTION; HUMANS
Identifiers
URN: urn:nbn:se:uu:diva-38031OAI: oai:DiVA.org:uu-38031DiVA: diva2:65930
Note
Addresses: Osterberg T, Pharmacia Corp, R&D, Preformulat Sci, SE-11287 Stockholm, Sweden. AstraZeneca R&D Sodertalje, SE-15185 Sodertalje, Sweden. Uppsala Univ, Biomed Ctr, Dept Biochem, SE-75123 Uppsala, Sweden.Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2011-01-14

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