Effects of environment on compensatory mutations to ameliorate costs of antibiotic resistance
2000 (English)In: Science, ISSN 0036-8075, Vol. 287, no 5457, 1479-1482 p.Article in journal (Refereed) Published
Most types of antibiotic resistance impose a biological cost on bacterial fitness. These costs can be compensated, usually without loss of resistance, by second-site mutations during the evolution of the resistant bacteria in an experimental host or in a laboratory medium. Different fitness-compensating mutations were selected depending on whether the bacteria evolved through serial passage in mice or in a laboratory medium. This difference in mutation spectra was caused by either a growth condition-specific formation or selection of the compensated mutants. These results suggest that bacterial evolution to reduce the costs of antibiotic resistance can take different trajectories within and outside a host.
Place, publisher, year, edition, pages
AMER ASSOC ADVANCEMENT SCIENCE , 2000. Vol. 287, no 5457, 1479-1482 p.
ESCHERICHIA-COLI, RIBOSOMES, GROWTH
IdentifiersURN: urn:nbn:se:uu:diva-38067DOI: 10.1126/science.287.5457.1479PubMedID: 10688795OAI: oai:DiVA.org:uu-38067DiVA: diva2:65966