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Effects of environment on compensatory mutations to ameliorate costs of antibiotic resistance
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology.
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology.
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Evolutionary Biology, Molecular Evolution.
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology.
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2000 (English)In: Science, ISSN 0036-8075, E-ISSN 1095-9203, Vol. 287, no 5457, 1479-1482 p.Article in journal (Refereed) Published
Abstract [en]

Most types of antibiotic resistance impose a biological cost on bacterial fitness. These costs can be compensated, usually without loss of resistance, by second-site mutations during the evolution of the resistant bacteria in an experimental host or in a laboratory medium. Different fitness-compensating mutations were selected depending on whether the bacteria evolved through serial passage in mice or in a laboratory medium. This difference in mutation spectra was caused by either a growth condition-specific formation or selection of the compensated mutants. These results suggest that bacterial evolution to reduce the costs of antibiotic resistance can take different trajectories within and outside a host.

Place, publisher, year, edition, pages
AMER ASSOC ADVANCEMENT SCIENCE , 2000. Vol. 287, no 5457, 1479-1482 p.
Keyword [en]
ESCHERICHIA-COLI, RIBOSOMES, GROWTH
National Category
Natural Sciences
Identifiers
URN: urn:nbn:se:uu:diva-38067DOI: 10.1126/science.287.5457.1479PubMedID: 10688795OAI: oai:DiVA.org:uu-38067DiVA: diva2:65966
Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2017-12-06Bibliographically approved

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Hughes, Diarmaid

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