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Origins of minigene-dependent growth inhibition in bacterial cells
Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Faculty of Science and Technology, Biology, Department of Cell and Molecular Biology.
2000 (English)In: EMBO JOURNAL, ISSN 0261-4189, Vol. 19, no 11, 2701-2709 p.Article in journal (Refereed) Published
Abstract [en]

The expression of very short open reading frames in Escherichia coli can lead to the inhibition of translation and an arrest in cell growth. Inhibition occurs because peptidyl-tRNA hydrolase fails to recycle sufficiently rapidly peptidyl-tRNA released fro

Place, publisher, year, edition, pages
OXFORD UNIV PRESS , 2000. Vol. 19, no 11, 2701-2709 p.
Keyword [en]
mini-gene; peptidyl-tRNA; release factor; ribosome recycling; translation termination; PEPTIDYL-TRANSFER-RNA; ESCHERICHIA-COLI RIBOSOMES; RECYCLING FACTOR RRF; RELEASE FACTOR RF3; PROTEIN-SYNTHESIS; TRANSLATION TERMINATION; HYDROLASE; EXPRESSION; CHAIN; S
Identifiers
URN: urn:nbn:se:uu:diva-38099OAI: oai:DiVA.org:uu-38099DiVA: diva2:65998
Note
Addresses: Ehrenberg M, Biomed Ctr, Dept Cell & Mol Biol, Box 596, S-75124 Uppsala, Sweden. Biomed Ctr, Dept Cell & Mol Biol, S-75124 Uppsala, Sweden. Inst Biol Physicochim, CNRS, UPR 9073, F-75005 Paris, France.Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2011-01-14

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