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Stochastic focusing: Fluctuation-enhanced sensitivity of intracellular regulation
Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Faculty of Science and Technology, Biology, Department of Cell and Molecular Biology.
Department of Evolutionary Biology.
2000 (English)In: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, Vol. 97, no 13, 7148-7153 p.Article in journal (Refereed) Published
Abstract [en]

Many regulatory molecules are present in low copy numbers per cell so that significant random fluctuations emerge spontaneously. Because cell viability depends on precise regulation of key events, such signal noise has been thought to impose a threat that

Place, publisher, year, edition, pages
NATL ACAD SCIENCES , 2000. Vol. 97, no 13, 7148-7153 p.
Keyword [en]
ESCHERICHIA-COLI; RESONANCE; SYSTEMS; AMPLIFICATION; MODEL; NOISE
Identifiers
URN: urn:nbn:se:uu:diva-38149OAI: oai:DiVA.org:uu-38149DiVA: diva2:66048
Note
Addresses: Paulsson J, Biomed Ctr, Dept Cell & Mol Biol, Box 596, SE-75124 Uppsala, Sweden. Biomed Ctr, Dept Cell & Mol Biol, SE-75124 Uppsala, Sweden. Evolutionary Biol Ctr, Dept Mol Evolut, SE-75263 Uppsala, Sweden.Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2011-01-14

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