uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Cortisol awakening response in late pregnancy in women with previous or ongoing depression
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Obstetrics and Gynaecology. (Reproduktiv hälsa/Sundström Poromaa)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Obstetrics and Gynaecology. (Obstetrisk forskning/Högberg)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Obstetrics and Gynaecology. (Reproduktiv hälsa/Sundström Poromaa)ORCID iD: 0000-0002-4935-7532
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Obstetrics and Gynaecology. (Reproduktiv hälsa/Sundström Poromaa)
2013 (English)In: Psychoneuroendocrinology, ISSN 0306-4530, E-ISSN 1873-3360, Vol. 38, no 12, 3150-3154 p.Article in journal (Refereed) Published
Abstract [en]

Pregnancy is associated with increased basal cortisol levels, and decreased hypothalamic-pituitary-adrenal (HPA) axis reactivity. The cortisol awakening response (CAR) is a measure of HPA-axis reactivity which has been reported to be increased in patients with ongoing depressive disorder and in individuals with remitted depression. In this study, we investigated HPA-axis reactivity in pregnant women with ongoing or previous depression. The CAR was assessed by measurement of salivary cortisol at awakening and 15, 30, and 45min post-awakening. Based on structured psychiatric interviews and repeated measurements of depressive symptoms during pregnancy, 134 women were included in one of the three groups: never depressed (n=57), depressed prior to the current pregnancy (n=39), and depressed during the current pregnancy (n=38). Given the prior findings of increased CAR in non-pregnant depressed subjects, we hypothesized that an ongoing or previous depression would result in a higher CAR. Contrary to our hypothesis, a mixed models analysis failed to yield significant group differences. Thus, our results suggest that never depressed pregnant women and women with depression during pregnancy have similar cortisol awakening responses. Furthermore, our findings suggest that the cortisol awakening response does not differ between currently healthy women with and without experience of a depressive episode during late pregnancy.

Place, publisher, year, edition, pages
2013. Vol. 38, no 12, 3150-3154 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-210063DOI: 10.1016/j.psyneuen.2013.08.007ISI: 000330824400033PubMedID: 24041544OAI: oai:DiVA.org:uu-210063DiVA: diva2:660717
Available from: 2013-10-30 Created: 2013-10-30 Last updated: 2017-12-06Bibliographically approved

Open Access in DiVA

fulltext(372 kB)197 downloads
File information
File name FULLTEXT01.pdfFile size 372 kBChecksum SHA-512
89ebe6329b0c50d0ae26ca2756b0b0cf21fadef5181799f7df2cfbe404f1cbdefad759629582aed48029ca1b069cd3514c72aab03465072444a9f5501007fb01
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Authority records BETA

Hellgren, CharlotteÅkerud, HelenaSkalkidou, AlkistisSundström-Poromaa, Inger

Search in DiVA

By author/editor
Hellgren, CharlotteÅkerud, HelenaSkalkidou, AlkistisSundström-Poromaa, Inger
By organisation
Obstetrics and Gynaecology
In the same journal
Psychoneuroendocrinology
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
Total: 197 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 577 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf