uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Is the Relationship between Prenatal Exposure to PCB-153 and Decreased Birth Weight Attributable to Pharmacokinetics?
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Environmental toxicology.
Show others and affiliations
2013 (English)In: Journal of Environmental Health Perspectives, ISSN 0091-6765, E-ISSN 1552-9924, Vol. 121, no 10, 1219-1224 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: A recent meta-analysis based on data from > 7,000 pregnancies reported an -association between prenatal polychlorinated biphenyl (PCB)-153 exposure and reduced birth weight. Gestational weight gain, which is associated negatively with PCB levels in maternal and cord blood, and positively with birth weight, could substantially confound this association. OBJECTIVE: We sought to estimate the influence of gestational weight gain on the association between PCB-153 exposure and birth weight using a pharmacokinetic model. METHODS: We modified a recently published pharmacokinetic model and ran Monte Carlo simulations accounting for variability in physiologic parameters and their correlations. We evaluated the pharmacokinetic model by comparing simulated plasma PCB-153 levels during pregnancy to serial measurements in 10 pregnant women from another study population. We estimated the association between simulated plasma PCB-153 levels and birth weight using linear regression models. RESULTS: The plasma PCB-153 level profiles generated with the pharmacokinetic model were comparable to measured levels in 10 pregnant women. We estimated a 118-g decrease in birth weight (95% CI: -129, -106 g) for each 1-mu g/L increase in simulated cord plasma PCB-153, compared with the 150-g decrease estimated based on the previous meta-analysis. The estimated decrease in birth weight was reduced to -6 g (95% CI: -18, 6 g) when adjusted for simulated gestational weight gain. CONCLUSION: Our findings suggest that associations previously noted between PCB levels and birth weight may be attributable to confounding by maternal weight gain during pregnancy.

Place, publisher, year, edition, pages
2013. Vol. 121, no 10, 1219-1224 p.
National Category
Medical and Health Sciences Natural Sciences
URN: urn:nbn:se:uu:diva-210194DOI: 10.1289/ehp.1206457ISI: 000325152400027OAI: oai:DiVA.org:uu-210194DiVA: diva2:661526
Available from: 2013-11-04 Created: 2013-11-04 Last updated: 2013-11-04Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text
By organisation
Environmental toxicology
In the same journal
Journal of Environmental Health Perspectives
Medical and Health SciencesNatural Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 254 hits
ReferencesLink to record
Permanent link

Direct link