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Cytochrome P450-dependent binding of 7,12-dimethylbenz[a]anthracene (DMBA) and benzo[a]pyrene (B[a]P) in murine heart, lung, and liver endothelial cells
Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Faculty of Science and Technology, Biology, Department of Evolutionary Biology.
2000 (English)In: ARCHIVES OF TOXICOLOGY, ISSN 0340-5761, Vol. 74, no 10, 593-601 p.Article in journal (Refereed) Published
Abstract [en]

Autoradiography was used to investigate the cellular sites of irreversible binding of H-3-labelled 7,12-dimethylbenz[a]anthracene (DMBA) and benzo[a]pyrene (B[a]P) in mice. Autoradiograms obtained from solvent-extracted tape-sections revealed an even dist

Place, publisher, year, edition, pages
SPRINGER-VERLAG , 2000. Vol. 74, no 10, 593-601 p.
Keyword [en]
7;12-dimethylbenz[a]anthracene; benzo[a]pyrene; PCB 126; endothelial cells; heart; lung; irreversible binding; P450 REDUCTASE; METABOLIC-ACTIVATION; HETEROCYCLIC AMINES; MESSENGER-RNA; MICE; ATHEROSCLEROSIS; INDUCTION; 3-METHYLCHOLANTHRENE; EXPRESSION; HY
URN: urn:nbn:se:uu:diva-38257OAI: oai:DiVA.org:uu-38257DiVA: diva2:66156
Addresses: Brandt I, Uppsala Univ, Evolutionary Biol Ctr, Dept Environm Toxicol, Norbyvagen 18A, S-75236 Uppsala, Sweden. Uppsala Univ, Evolutionary Biol Ctr, Dept Environm Toxicol, S-75236 Uppsala, Sweden.Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2011-01-14

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