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Nutrient intakes independently affect growth in extremely preterm infants: results from a population-based study
Department of Clinical Sciences, Paediatrics, Umeå University, Sweden.
Department of Clinical Sciences, Paediatrics, Umeå University, Sweden.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health. (Barnendokrinologisk forskning/Gustafsson)
Institute of Clinical Sciences, Section for the Health of Women and Children, Sahlgrenska Academy at University of Gothenburg, Sweden.
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2013 (English)In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 102, no 11, 1067-1074 p.Article in journal (Refereed) Published
Abstract [en]

AimTo explore associations between energy and macronutrient intakes and early growth in extremely low gestational age (ELGA) infants. MethodsRetrospective population-based study of all ELGA infants (<27weeks) born in Sweden during 2004-2007. Detailed data on nutrition and anthropometric measurements from birth to 70days of postnatal age were retrieved from hospital records. ResultsStudy infants (n=531) had a meanSD gestational age of 25.3 +/- 1.1weeks and a birth weight of 765 +/- 170g. Between 0 and 70days, average daily energy and protein intakes were 120 +/- 11kcal/kg and 3.2 +/- 0.4g/kg, respectively. During this period, standard deviation scores for weight, length and head circumference decreased by 1.4, 2.3 and 0.7, respectively. Taking gestational age, baseline anthropometrics and severity of illness into account, lower energy intake correlated with lower gain in weight (r=+0.315, p<0.001), length (r=+0.215, p<0.001) and head circumference (r=+0.218, p<0.001). Protein intake predicted growth in all anthropometric outcomes, and fat intake was positively associated with head circumference growth. ConclusionExtremely low gestational age infants received considerably less energy and protein than recommended and showed postnatal growth failure. Nutrient intakes were independent predictors of growth even after adjusting for severity of illness. These findings suggest that optimized energy and macronutrient intakes may prevent early growth failure in these infants.

Place, publisher, year, edition, pages
2013. Vol. 102, no 11, 1067-1074 p.
Keyword [en]
Energy intake, Extremely preterm infants, Growth failure, Nutrient intake, Protein
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-210169DOI: 10.1111/apa.12359ISI: 000325265500021OAI: oai:DiVA.org:uu-210169DiVA: diva2:661657
Available from: 2013-11-04 Created: 2013-11-04 Last updated: 2014-01-13Bibliographically approved

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