Biological cost and compensatory evolution in fusidic acid-resistant Staphylococcus aureus
2001 (English)In: Molecular Microbiology, ISSN 0950-382X, E-ISSN 1365-2958, Vol. 40, no 2, 433-439 p.Article in journal (Refereed) Published
Fusidic acid resistance resulting from mutations in elongation factor G (EF-G) of Staphylococcus aureus is associated with fitness costs during growth in vivo and in vitro. In both environments, these costs can be partly or fully compensated by the acquisition of secondary intragenic mutations. Among clinical isolates of S. aureus, fusidic acid-resistant strains have been identified that carry multiple mutations in EF-G at positions similar to those shown experimentally to cause resistance and fitness compensation. This observation suggests that fitness-compensatory mutations may be an important aspect of the evolution of antibiotic resistance in the clinical environment, and may contribute to a stabilization of the resistant bacteria present in a bacterial population.
Place, publisher, year, edition, pages
BLACKWELL SCIENCE LTD , 2001. Vol. 40, no 2, 433-439 p.
IdentifiersURN: urn:nbn:se:uu:diva-38289DOI: 10.1046/j.1365-2958.2001.02389.xPubMedID: 11309125OAI: oai:DiVA.org:uu-38289DiVA: diva2:66188
Addresses: Hughes D, Biomed Ctr, Dept Cell & Mol Biol, Box 596, S-75124 Uppsala, Sweden. Biomed Ctr, Dept Cell & Mol Biol, S-75124 Uppsala, Sweden. Swedish Inst Infect Dis Control, Dept Bacteriol, S-17182 Solna, Sweden.2008-10-172008-10-172011-07-18Bibliographically approved