uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Biological cost and compensatory evolution in fusidic acid-resistant Staphylococcus aureus
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology.
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology.
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology.
2001 (English)In: Molecular Microbiology, ISSN 0950-382X, E-ISSN 1365-2958, Vol. 40, no 2, 433-439 p.Article in journal (Refereed) Published
Abstract [en]

Fusidic acid resistance resulting from mutations in elongation factor G (EF-G) of Staphylococcus aureus is associated with fitness costs during growth in vivo and in vitro. In both environments, these costs can be partly or fully compensated by the acquisition of secondary intragenic mutations. Among clinical isolates of S. aureus, fusidic acid-resistant strains have been identified that carry multiple mutations in EF-G at positions similar to those shown experimentally to cause resistance and fitness compensation. This observation suggests that fitness-compensatory mutations may be an important aspect of the evolution of antibiotic resistance in the clinical environment, and may contribute to a stabilization of the resistant bacteria present in a bacterial population.

Place, publisher, year, edition, pages
BLACKWELL SCIENCE LTD , 2001. Vol. 40, no 2, 433-439 p.
National Category
Natural Sciences
Identifiers
URN: urn:nbn:se:uu:diva-38289DOI: 10.1046/j.1365-2958.2001.02389.xPubMedID: 11309125OAI: oai:DiVA.org:uu-38289DiVA: diva2:66188
Note
Addresses: Hughes D, Biomed Ctr, Dept Cell & Mol Biol, Box 596, S-75124 Uppsala, Sweden. Biomed Ctr, Dept Cell & Mol Biol, S-75124 Uppsala, Sweden. Swedish Inst Infect Dis Control, Dept Bacteriol, S-17182 Solna, Sweden.Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2017-12-06Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Authority records BETA

Hughes, Diarmaid

Search in DiVA

By author/editor
Hughes, Diarmaid
By organisation
Department of Cell and Molecular Biology
In the same journal
Molecular Microbiology
Natural Sciences

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 601 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf