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The role of zinc in the dark-adapted retina studied directly using microPIXE
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Physical and Analytical Chemistry, Surface Biotechnology, Centre for Surface Biotechnology.
2001 (English)In: Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, ISSN 0168-583X, E-ISSN 1872-9584, Vol. 181, 489-492 p.Article in journal (Refereed) Published
Abstract [en]

Zinc deficiency is known to cause night blindness, which can be reverted by the administration of zinc.The exact function of zinc is not understood but it is likely that zinc plays a unique role in thephototransduction process and/or photoreceptor/retinal pigment interaction. The localisation of free (histochemically reactive) zinc within the photoreceptors changes with light stimulation [Exp. Eye Res. (1999) 459]. In the dark-adapted retina chelatable zinc can be visualised primarily in the perikarya, whereas after photostimulation free zinc is mainly associated with the inner segments. This variation might be due to (1) a translocation of zinc from the perikarya to the inner segments, (2) a change in thestate of zinc (from a free to a bound form, histochemically and non-histochemically reactive, respectively), or (3) zinc influx and/or efflux across the plasma membrane. MicroPIXE was used to analyse the total (free and bound) zinc distribution in each retinal layer and a difference was found between light- and dark-adapted retinas (preliminary data). Following light stimulation the most pronounced difference in the zinc concentration was found in the inner segments of the photoreceptors and the layer containing the photoreceptors perikarya (outer nuclear layer).

Place, publisher, year, edition, pages
2001. Vol. 181, 489-492 p.
Keyword [en]
MicroPIXE, free zinc, bound zinc, retina, adaptation, data-acquisition, localization, package
National Category
Natural Sciences
Identifiers
URN: urn:nbn:se:uu:diva-38396DOI: 10.1016/S0168-583X(01)00478-5ISI: 000170885400086OAI: oai:DiVA.org:uu-38396DiVA: diva2:66295
Conference
7th International Conference on Nuclear Microprobe Technology and Applications; Bordeaux, France; SEP 10-15, 2000
Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2017-12-06Bibliographically approved

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