uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Estrogenic influences in pain processing
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Clinical Neurophysiology.
2013 (English)In: Frontiers in neuroendocrinology (Print), ISSN 0091-3022, E-ISSN 1095-6808, Vol. 34, no 4, 329-349 p.Article, review/survey (Refereed) Published
Abstract [en]

Gonadal hormones not only play a pivotal role in reproductive behavior and sexual differentiation, they also contribute to thermoregulation, feeding, memory, neuronal survival, and the perception of somatosensory stimuli. Numerous studies on both animals and human subjects have also demonstrated the potential effects of gonadal hormones, such as estrogens, on pain transmission. These effects most likely involve multiple neuroanatomical circuits as well as diverse neurochemical systems and they therefore need to be evaluated specifically to determine the localization and intrinsic characteristics of the neurons engaged. The aim of this review is to summarize the morphological as well as biochemical evidence in support for gonadal hormone modulation of nociceptive processing, with particular focus on estrogens and spinal cord mechanisms.

Place, publisher, year, edition, pages
2013. Vol. 34, no 4, 329-349 p.
Keyword [en]
Nociception, Gonadal hormones, Estrogens, Estrogen receptors, Spinal dorsal horn, Medullary dorsal horn, Steroid hormones, Enkephalin, Opioid, Pain mechanisms
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-210938DOI: 10.1016/j.yfrne.2013.06.001ISI: 000325737300007OAI: oai:DiVA.org:uu-210938DiVA: diva2:664890
Available from: 2013-11-18 Created: 2013-11-18 Last updated: 2013-11-18Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Amandusson, Åsa
By organisation
Clinical Neurophysiology
In the same journal
Frontiers in neuroendocrinology (Print)
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 307 hits
ReferencesLink to record
Permanent link

Direct link