uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Long-term effects of acute low-dose ionizing radiation on the neonatal mouse heart: a proteomic study
Show others and affiliations
2013 (English)In: Radiation and Environmental Biophysics, ISSN 0301-634X, E-ISSN 1432-2099, Vol. 52, no 4, 451-461 p.Article in journal (Refereed) Published
Abstract [en]

Epidemiological studies establish that children and young adults are especially susceptible to radiation-induced cardiovascular disease (CVD). The biological mechanisms behind the elevated CVD risk following exposure at young age remain unknown. The present study aims to elucidate the long-term effects of ionizing radiation by studying the murine cardiac proteome after exposure to low and moderate radiation doses. NMRI mice received single doses of total body Co-60 gamma-irradiation on postnatal day 10 and were sacrificed 7 months later. Changes in cardiac protein expression were quantified using isotope-coded protein label and tandem mass spectrometry. We identified 32, 31, 66, and 34 significantly deregulated proteins after doses of 0.02, 0.1, 0.5, and 1.0 Gy, respectively. The four doses shared 9 deregulated proteins. Bioinformatics analysis showed that most of the deregulated proteins belonged to a limited set of biological categories, including metabolic processes, inflammatory response, and cytoskeletal structure. The transcription factor peroxisome proliferator-activated receptor alpha was predicted as a common upstream regulator of several deregulated proteins. This study indicates that both adaptive and maladaptive responses to the initial radiation damage persist well into adulthood. It will contribute to the understanding of the long-term consequences of radiation-induced injury and developmental alterations in the neonatal heart.

Place, publisher, year, edition, pages
2013. Vol. 52, no 4, 451-461 p.
Keyword [en]
Low-dose ionizing radiation, Acute exposure, Total body irradiation, Cardiac effects, Fibrinogen, PPAR alpha, Proteomics, ICPL
National Category
Natural Sciences
URN: urn:nbn:se:uu:diva-211019DOI: 10.1007/s00411-013-0483-8ISI: 000326074900003OAI: oai:DiVA.org:uu-211019DiVA: diva2:665482
Available from: 2013-11-20 Created: 2013-11-19 Last updated: 2013-11-20Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Eriksson, PerBuratovic, Sonja
By organisation
Environmental toxicology
In the same journal
Radiation and Environmental Biophysics
Natural Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 248 hits
ReferencesLink to record
Permanent link

Direct link