uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Peroxovanadate but not vanadate exerts insulin-like effects in human adipocytes
Department of Medicine, University of Göteborg, Göteborg, Sweden .
1993 (English)In: Diabetologia, ISSN 0012-186X, E-ISSN 1432-0428, Vol. 36, no 2, 113-116 p.Article in journal (Refereed) Published
Abstract [en]

Vanadate and peroxovanadate were recently reported to exert maximal or even supramaximal (peroxovanadate) insulin-like effects in rat adipocytes. To evaluate the response in human cells, isolated human adipocytes were exposed to insulin or various concentrations of vanadate (0-10 mmol/l) or peroxovanadate (0-5 mmol/l). Neither vanadate nor peroxovanadate affected 125I-insulin binding and insulin sensitivity. Vanadate exerted no apparent effect on 14C-U-glucose uptake, whereas 0.1 mmol/l peroxovanadate exerted a full insulin-like response (p < 0.001). No additive response was observed by combining either vanadate or peroxovanadate with insulin. Peroxovanadate at 0.1 mmol/l was as effective as insulin in inhibiting isoproterenol-stimulated lipolysis. Neither peroxovanadate nor insulin-inhibited lipolysis stimulated by N6-monobutyryl-cAMP, an analogue which is not hydrolysed by the cAMP-phosphodiesterase. It is concluded that peroxovanadate, but not vanadate, elicits a full insulin-like response in human adipocytes.

Place, publisher, year, edition, pages
1993. Vol. 36, no 2, 113-116 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-211338DOI: 10.1007/BF00400690PubMedID: 8458524OAI: oai:DiVA.org:uu-211338DiVA: diva2:665996
Available from: 2013-11-21 Created: 2013-11-21 Last updated: 2013-11-22Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Eriksson, Jan W
In the same journal
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 132 hits
ReferencesLink to record
Permanent link

Direct link