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Insulin concentrations and insulin sensitivity after short-term amiloride in healthy subjects
Department of Medicine, University of Göteborg, Sahlgren's Hospital, Göteborg, Sweden .
1994 (English)In: European Journal of Clinical Pharmacology, ISSN 0031-6970, E-ISSN 1432-1041, Vol. 46, no 5, 469-472 p.Article in journal (Refereed) Published
Abstract [en]

We have evaluated the short-term effects of amiloride on insulin action in vivo, since amiloride is known to impair insulin action in vitro.

Seven healthy subjects were treated according to a randomized, double-blind, cross-over protocol. The treatment periods were 3 days each with amiloride 15 mg daily and placebo. Insulin action on glucose turnover was assessed directly after each treatment period with the hyper-insulinaemic euglycaemic glucose clamp technique.

At the two insulin concentrations studied (∼ 30 mU·l−1 and ∼ 200 mU·l−1), the glucose infusion rate required to maintain constant euglycaemia did not differ after either amiloride or placebo. The rates of glucose production and utilization were also similar, whereas the so-called insulin sensitivity index at the lower insulin concentration was significantly reduced (by about 15 %) after amiloride. Moreover, amiloride produced significantly higher fasting insulin and C-peptide concentrations, whereas fasting glucose and NEFA concentrations were unaltered.

In conclusion, these data suggest that short-term amiloride slightly impairs insulin sensitivity with respect to glucose uptake. However, overall glucose homoeostasis does not appear to be affected, probably due to a compensatory rise in plasma insulin.

Place, publisher, year, edition, pages
1994. Vol. 46, no 5, 469-472 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-211336DOI: 10.1007/BF00191913PubMedID: 7957545OAI: oai:DiVA.org:uu-211336DiVA: diva2:665997
Available from: 2013-11-21 Created: 2013-11-21 Last updated: 2013-11-22Bibliographically approved

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