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Cellular cyclic AMP levels modulate insulin sensitivity and responsiveness: evidence against a significant role of Gi in insulin signal transduction
Gothenburg University, Sahlgrens Hospital, Department of Medicine, Gothenburg, Sweden.
1993 (English)In: Biochemical and Biophysical Research Communications - BBRC, ISSN 0006-291X, E-ISSN 1090-2104, Vol. 196, no 1, 287-293 p.Article in journal (Refereed) Published
Abstract [en]

Treating rats with pertussis toxin (PTX) both elevated the adipocyte cAMP levels and impaired sensitivity and responsiveness to the antilipolytic effect of insulin in the presence of different beta-adrenergic agonists. However, in the presence of a fixed medium concentration of the degradable cAMP analogue, 8-bromo-cAMP, the effect of insulin was similar in PTX- and control cells. Elevating the cAMP levels in control cells either through different concentrations of the cAMP analogue or addition of adenosine deaminase impaired both insulin sensitivity and responsiveness to a similar extent as that seen in PTX-treated cells. The antilipolytic effect of insulin was exerted through the activation of the cGMP-inhibitable phosphodiesterase (cGI-PDE) as it was dose-dependently impaired by the specific cGI-PDE inhibitor OPC 3911. The results show the importance of the cellular cAMP levels in modulating insulin sensitivity and action. Gi plays a minor role, if any, for the signal transduction of the antilipolytic effect of insulin.

Place, publisher, year, edition, pages
1993. Vol. 196, no 1, 287-293 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-211337DOI: 10.1006/bbrc.1993.2247PubMedID: 8216302OAI: oai:DiVA.org:uu-211337DiVA: diva2:665998
Available from: 2013-11-21 Created: 2013-11-21 Last updated: 2013-11-29Bibliographically approved

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