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Neuroendocrine mechanisms in insulin resistance
The Lundberg Laboratory for Diabetes Research, Department of Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden.
2009 (English)In: Molecular and Cellular Endocrinology, ISSN 0303-7207, E-ISSN 1872-8057, Vol. 297, no 1-2, 104-111 p.Article in journal (Refereed) Published
Abstract [en]

Dysregulated hormonal, metabolic and neural signalling within and between organs can contribute to development of metabolic diseases including type 2 diabetes. Insulin-antagonistic effects of hormones, cytokines and excess metabolic substrates such as glucose and fatty acids may be exerted via common mechanisms involving for example reactive oxygen species (ROS) accumulation and associated inflammatory responses. Visceral adiposity is a central component of the metabolic syndrome and it is also strongly associated with insulin resistance. Both visceral obesity and insulin resistance are important risk factors for the development of type 2 diabetes. In the development of insulin resistance, it is likely that intra-abdominal adipose tissue plays a critical role in a complex endocrine and neural network involving several tissues. This review paper focuses on neuroendocrine 'stress' factors that target insulin-responsive tissues, in particular adipose tissue. We propose that there are common pathways by which dysregulation in different endocrine systems may contribute to the development of type 2 diabetes.

Place, publisher, year, edition, pages
2009. Vol. 297, no 1-2, 104-111 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-211254DOI: 10.1016/j.mce.2008.05.010PubMedID: 18599191OAI: oai:DiVA.org:uu-211254DiVA: diva2:666213
Available from: 2013-11-22 Created: 2013-11-21 Last updated: 2013-11-28Bibliographically approved

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