An Improved Palladium(II)-Catalyzed Method for the Synthesis of Aryl Ketones from Aryl Carboxylic Acids and Organonitriles
2014 (English)In: Tetrahedron Letters, ISSN 0040-4039, E-ISSN 1873-3581, Vol. 55, no 15, 2376-2380 p.Article in journal (Refereed) Published
A palladium(II)-catalyzed decarboxylative protocol for the synthesis of aryl ketones has been developed. The addition of TFA was shown to improve the reaction yield and employing THF as solvent enabled the use of solid nitriles and in only a small excess. Using this method, five different benzoic acids reacted with a wide range of nitriles to produce 29 diverse (hetero)aryl ketone derivatives in up to 94% yield.
Place, publisher, year, edition, pages
2014. Vol. 55, no 15, 2376-2380 p.
Organic Chemistry Engineering and Technology
Research subject Engineering Science with specialization in Nanotechnology and Functional Materials
IdentifiersURN: urn:nbn:se:uu:diva-211660DOI: 10.1016/j.tetlet.2014.02.109ISI: 000334977100012OAI: oai:DiVA.org:uu-211660DiVA: diva2:667820
FunderKnut and Alice Wallenberg Foundation