uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
A Rank-Order Procedure Applied to an Ethoexperimental Behavior Model—The Multivariate Concentric SquareField™ (MCSF) Test
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Pharmacology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences. (Neuropharmacology, Addiction and Behaviour)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences. (Neuropharmacology, Addiction and Behaviour)
2013 (English)In: Journal of Behavioral and Brain Science, ISSN 2160-5866, E-ISSN 2160-5874, Vol. 3, no 4, 350-361 p.Article in journal (Refereed) Published
Abstract [en]

Designing relevant animal models in order to investigate the neurobiological basis for human mental disorders is an important challenge. The need for new tests to be developed and traditional tests to be improved has recently been em-phasized. The authors propose a multivariate test approach, the multivariate concentric square fieldTM (MCSF) test. To measure and evaluate variation in the behavioral traits, we here put forward a statistical procedure of which the working title is “trend analysis”. Low doses of the benzodiazepine agonist diazepam (DZP; 1.0, 1.5, or 2.0 mg/kg) were used for exploring the use of the trend analysis in combination with multivariate data analysis for assessment of MCSF per-formance in rats. The commonly used elevated plus maze (EPM) test was used for comparison. The trend analysis comparing vehicle and the DZP1.5 groups revealed significantly higher general activity and risk-taking behavior in the DZP1.5 rats relative to vehicle rats. This finding was supported by multivariate data analysis procedures. It is concluded that the trend analysis together with multivariate data analysis procedures offers possibilities to extract information and illustrates effects obtained in the MCSF test. Diazepam in doses that have no apparent increase in open arm activity in the EPM was effective to alter the behavior in the MCSF test. The MCSF test and the use of multivariate data analysis and the proposed trend analysis may be useful alternatives to behavioral test batteries and traditionally used tests for the understanding of mechanisms underlying various mental states. Finally, the impact of an ethological reasoning and multivariate measures enabling behavioral profiling of animals may be a useful complementary methodology when phenotyping animals in behavioral neuroscience.

Place, publisher, year, edition, pages
2013. Vol. 3, no 4, 350-361 p.
National Category
Neurosciences
Identifiers
URN: urn:nbn:se:uu:diva-211677DOI: 10.4236/jbbs.2013.34035OAI: oai:DiVA.org:uu-211677DiVA: diva2:667956
Available from: 2013-11-28 Created: 2013-11-28 Last updated: 2017-12-06Bibliographically approved

Open Access in DiVA

fulltext(1458 kB)99 downloads
File information
File name FULLTEXT01.pdfFile size 1458 kBChecksum SHA-512
25725dec9b3fc915d27329affe0d293e5a9bf2770a7ec9e22afcb3508c4414bdbfbe73b5139b6eb310189b553a7ffdaa5be9e25534c4447404e9fddeb3d812a8
Type fulltextMimetype application/pdf

Other links

Publisher's full text

Authority records BETA

Meyerson, Bengt JRoman, Erika

Search in DiVA

By author/editor
Meyerson, Bengt JRoman, Erika
By organisation
PharmacologyDepartment of Pharmaceutical Biosciences
In the same journal
Journal of Behavioral and Brain Science
Neurosciences

Search outside of DiVA

GoogleGoogle Scholar
Total: 99 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 714 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf