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Loss of 5-Hydroxymethylcytosine and TET2 in Oral Squamous Cell Carcinoma
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2013 (English)In: Anticancer Research, ISSN 0250-7005, E-ISSN 1791-7530, Vol. 33, no 10, 4325-4328 p.Article in journal (Refereed) Published
Abstract [en]

Aim: Epigenetic modifications, such as DNA methylation, are considered important in the regulation of target genes in cancer development. 5-Hydroxymethylcytosine (5hmC) was recently discovered to be related to the process of malignant transformation. The influence of DNA methylation in oral squamous cell carcinomas (OSCC) is not fully- understood. Therefore, the aim of the present study was to investigate the DNA methylation pattern in OSCC compared to healthy oral epithelium. Materials and Methods: Oral mucosal samples from patients with OSCC (n=15) and healthy mucosa (n=12) were analyzed using immunohistochemistry with antibodies against 5hmC, 5mC and ten-eleven-translocation-2 (TET2). Results: A significant decrease in 5hmC and TET2 expression was found in OSCC compared to healthy oral epithelium. In contrast, there was a significant increase in 5mC expression in OSCC compared to healthy epithelium. Conclusion: Our results indicate that loss of 5hmC is an epigenetic event of OSCC.

Place, publisher, year, edition, pages
2013. Vol. 33, no 10, 4325-4328 p.
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Medical and Health Sciences
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URN: urn:nbn:se:uu:diva-211893ISI: 000326204400023PubMedID: 24122999OAI: oai:DiVA.org:uu-211893DiVA: diva2:670486
Available from: 2013-12-03 Created: 2013-12-03 Last updated: 2017-12-06Bibliographically approved

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Sand, Lars

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