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Closo-dodecaborate(2-)anion as a potential prosthetic group for attachment of astatine to proteins: Aspects of the labelling chemistry with Chloramine -T
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology.ORCID iD: 0000-0001-6120-2683
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology.
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2000 (English)In: Journal of labelled compounds & radiopharmaceuticals, ISSN 0362-4803, Vol. 43, no 3, 251-260 p.Article in journal (Other academic) Published
Abstract [en]

Closo-dodecarborate (2-) was proposed as a prosthetic group for direct labelling of proteins with 211At for radionuclide therapy. Astatination of closo-dodecarborate (2-) anion using Chloramine-T was studied, and the influence of pH, reaction time, amount of substrate and oxidant was determined. A maximum labelling yield of 55-75% was found in the pH range 7-8. A spontaneous astatination of closo-dodecarborate (2-) in the absence of Chloramine-T was also found, presumably due to generation of oxidising products from water radiolysis. Our results indicate that derivatives of closo-dodecarborate (2-) anion may be used as prosthetic groups for direct labelling of proteins.

Place, publisher, year, edition, pages
2000. Vol. 43, no 3, 251-260 p.
Keyword [en]
Closo-dodecaborate (2-) anion, 211At, Astatination, Chloramine-T
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-39285OAI: oai:DiVA.org:uu-39285DiVA: diva2:67184
Note
Adress: Sjöberg S., Univ Uppsala, Inst Chem, Box 531, S-75121 Uppsala, SwedenAvailable from: 2008-06-08 Created: 2008-06-08 Last updated: 2015-03-24Bibliographically approved

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Orlova, AnnaTolmachev, VladimirLundqvist, Hans

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