Closo-dodecaborate(2-)anion as a potential prosthetic group for attachment of astatine to proteins: Aspects of the labelling chemistry with Chloramine -T
2000 (English)In: Journal of labelled compounds & radiopharmaceuticals, ISSN 0362-4803, Vol. 43, no 3, 251-260 p.Article in journal (Other academic) Published
Closo-dodecarborate (2-) was proposed as a prosthetic group for direct labelling of proteins with 211At for radionuclide therapy. Astatination of closo-dodecarborate (2-) anion using Chloramine-T was studied, and the influence of pH, reaction time, amount of substrate and oxidant was determined. A maximum labelling yield of 55-75% was found in the pH range 7-8. A spontaneous astatination of closo-dodecarborate (2-) in the absence of Chloramine-T was also found, presumably due to generation of oxidising products from water radiolysis. Our results indicate that derivatives of closo-dodecarborate (2-) anion may be used as prosthetic groups for direct labelling of proteins.
Place, publisher, year, edition, pages
2000. Vol. 43, no 3, 251-260 p.
Closo-dodecaborate (2-) anion, 211At, Astatination, Chloramine-T
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-39285OAI: oai:DiVA.org:uu-39285DiVA: diva2:67184
Adress: Sjöberg S., Univ Uppsala, Inst Chem, Box 531, S-75121 Uppsala, Sweden2008-06-082008-06-082015-03-24Bibliographically approved