uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Staphylococcus aureus enterotoxin-specific IgE is associated with asthma in the general population: a GA(2)LEN study
Show others and affiliations
2013 (English)In: Allergy. European Journal of Allergy and Clinical Immunology, ISSN 0105-4538, E-ISSN 1398-9995, Vol. 68, no 10, 1289-1297 p.Article in journal (Refereed) Published
Abstract [en]


Specific IgE to Staphylococcus aureus enterotoxins (SE-IgE) has been associated with asthma. In the general population, we aimed to determine the prevalence of and risk factors for serum SE-IgE and to examine the association with asthma.


A postal questionnaire was sent to a random sample of adults in 19 centers across Europe. A random sample of respondents was invited for clinical examination upon which they answered a questionnaire, underwent skin prick tests (SPTs) for common aeroallergens, and provided blood for measurement of total IgE and SE-IgE. Risks were analyzed within centers using weighted logistic regression, and overall estimates calculated using fixed-effects meta-analysis.


2908 subjects were included in this analysis. Prevalence of positive SE-IgE was 29.3%; no significant geographic variation was observed. In contrast to positive skin prick tests, SE-IgE was more common in smokers (<15 pack-year: OR 1.11, P=0.079, 15 pack-year: OR 1.70, P<0.001), and prevalence did not decrease in older age-groups or in those with many siblings. Total IgE concentrations were higher in those with positive SE-IgE than in those with positive SPT. SE-IgE was associated with asthma (OR 2.10, 95% confidence interval [1.60-2.76], P=0.001) in a concentration-dependent manner. This effect was independent of SPT result and homogeneous across all centers.


We report for the first time that SE-IgE is common in the general population throughout Europe and that its risk factors differ from those of IgE against aeroallergens. This is the first study to show that SE-IgE is significantly and independently associated with asthma in the general population.

Place, publisher, year, edition, pages
2013. Vol. 68, no 10, 1289-1297 p.
Keyword [en]
asthma, epidemiology, IgE, Staphylococcus aureus, superantigens
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-212343DOI: 10.1111/all.12230ISI: 000326024300009OAI: oai:DiVA.org:uu-212343DiVA: diva2:677585

De två (2) första författarna delar förstaförfattarskapet.

Available from: 2013-12-10 Created: 2013-12-09 Last updated: 2013-12-10Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Janson, Christer
By organisation
Respiratory Medicine and Allergology
In the same journal
Allergy. European Journal of Allergy and Clinical Immunology
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 134 hits
ReferencesLink to record
Permanent link

Direct link