Iridium-Catalyzed Asymmetric Hydrogenation of Substituted Pyridines
2013 (English)In: Asian Journal of Organic Chemistry, ISSN 2193-5807, Vol. 2, no 12, 1061-1065 p.Article in journal (Refereed) Published
Asymmetric hydrogenation of ortho-substituted pyridines catalyzed by N,P-ligated iridium is demonstrated. To facilitate this reaction, the aromaticity of the pyridines was weakened by forming N-iminopyridium ylides. The reactions give very high conversions, and after a single recrystallization, excellent ee of up to 98 % was obtained. This method lends itself to the synthesis of chiral piperidine building blocks.
Place, publisher, year, edition, pages
2013. Vol. 2, no 12, 1061-1065 p.
hydrogenation, iridium, N-iminopyridium ylides, pyridines, selective catalysis
Organic Chemistry Inorganic Chemistry
Research subject Organic Chemistry
IdentifiersURN: urn:nbn:se:uu:diva-212412DOI: 10.1002/ajoc.201300160ISI: 000328218000008OAI: oai:DiVA.org:uu-212412DiVA: diva2:677721