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RhoD Binds the Rab5 Effector Rabankyrin-5 and has a Role in Trafficking of the Platelet-derived Growth Factor Receptor
Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Box 280, Nobels v¨ag 16, SE-171 77, Stockholm, Sweden.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Ludwig Institute for Cancer Research.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Ludwig Institute for Cancer Research.
1Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Box 280, Nobels v¨ag 16, SE-171 77, Stockholm, Sweden.
2013 (English)In: Traffic: the International Journal of Intracellular Transport, ISSN 1398-9219, E-ISSN 1600-0854, Vol. 14, no 12, 1242-1254 p.Article in journal (Refereed) Published
Abstract [en]

RhoD is a member of the classical Rho GTPases and it has essential roles in the regulation of actin dynamics. RhoD localizes to early endosomes and recycling endosomes, which indicates its important role in the regulation of endosome trafficking. Here, we show that RhoD binds to the Rab5 effector Rabankyrin-5, and RhoD and Rabankyrin-5 colocalize to Rab5-positive endosomes, which suggests a role for Rabankyrin-5 in the coordination of RhoD and Rab5 in endosomal trafficking. Interestingly, depletion of RhoD using siRNA techniques interfered with the internalization of the PDGF receptor and the subsequent activation of the downstream signaling cascades. Our data suggest that RhoD and Rabankyrin-5 have important roles in coordinating RhoD and Rab activities during internalization and trafficking of activated tyrosine kinase receptors.

Place, publisher, year, edition, pages
2013. Vol. 14, no 12, 1242-1254 p.
Keyword [en]
Endosome, PDGF receptor, Rho GTPases, RhoD, Rab5, Rabankyrin-5
National Category
Cell and Molecular Biology Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-212298DOI: 10.1111/tra.12121ISI: 000326727300007OAI: oai:DiVA.org:uu-212298DiVA: diva2:677771
Note

Posten finns som dubblett i Web of Science, med annat ISI-id: 000339892100006

Available from: 2013-12-10 Created: 2013-12-09 Last updated: 2017-12-06Bibliographically approved

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Voytyuk, OleksandrLennartsson, Johan

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