Persistent organic pollutants and abnormal geometry of the left ventricle in the elderly
2013 (English)In: Journal of Hypertension, ISSN 0263-6352, E-ISSN 1473-5598, Vol. 31, no 8, 1547-1553 p.Article in journal (Refereed) Published
Established risk factors for left ventricular hypertrophy (LVH) are hypertension, diabetes, and obesity. However, as these risk factors explain only part of the variation in left ventricular mass, we investigated whether persistent organic pollutants (POPs) might also play a role in LVH, because exposure to polychlorinated biphenyl 126 induced cardiac growth in rats.
In the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS), left ventricular mass index (LVMI), relative wall thickness (RWT), and geometric groups of LVH, were determined by echocardiography and 21 POPs were measured by high-resolution chromatography coupled to high-resolution mass spectrometry (HRGC/HRMS) in 1016 individuals aged 70 years. All individuals with a history of myocardial infarction were excluded from analysis (n=72).
Several of the POPs were related to abnormal left ventricular geometry before adjustment for established risk factors, but lost in significance following adjustment. However, the pesticide hexachlorobenzene (HCB) levels were significantly related to RWT, and concentric left ventricular remodeling, also following adjustment for sex, blood pressure, antihypertensive treatment, diabetes, and BMI (P<0.0001).
In this cross-sectional study, circulating levels of HCB were related to increased wall thickness of the left ventricle and concentric left ventricular remodeling, independently of LVH risk factors, suggesting a role of this environmental contaminant in abnormal growth of the left ventricle.
Place, publisher, year, edition, pages
2013. Vol. 31, no 8, 1547-1553 p.
echocardiography, elderly, hexachlorobenzene, left ventricular hypertrophy, persistent organic pollutants, pesticides, polychlorinated biphenyls
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-212428DOI: 10.1097/HJH.0b013e32836221b3ISI: 000326598600010OAI: oai:DiVA.org:uu-212428DiVA: diva2:677861