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A microfluidic approach for dynamic investigation of the antibiotic susceptibility of bacteria
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Microsystems Technology.
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Microsystems Technology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Microsystems Technology.
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2013 (English)In: MME 2013 24th Micromechanics and Microsystems Europe Conference, 2013Conference paper, Published paper (Refereed)
Abstract [en]

The possibility to study the effect on cell growth of a chemical is a valued tool for re- searchers in different areas, such as antibiotic resis- tance, cancer research and metabolic pathways. Traditional approaches need long time and no dynamic information is given. Microfluidics offers short diffusion lengths and steeper gradients for studies of antibiotic susceptibility, which could improve throughput greatly. By combining with time-lapse micrography, information on the dynam- ics may provide additional understanding. A micro- fluidic 3D cell culture chip was used to determine the MIC (minimum inhibitory concentration) and the dynamics of sub-MIC of E. coli against ampicillin and spectinomycin. And the same works have been done in Staphylococcus aureus and Salmonella. It is the first time to reveal this dynamic behaviour of bacteria against antibiotics quantitatively in a micro- fludic device. It is anticipated that it could be ex- tended to many other similar investigations in bio- logical and relevant pharmaceutical or clinical applications.

Place, publisher, year, edition, pages
2013.
National Category
Medical Engineering
Research subject
Engineering Science with specialization in Microsystems Technology
Identifiers
URN: urn:nbn:se:uu:diva-212491OAI: oai:DiVA.org:uu-212491DiVA: diva2:678044
Conference
MME 2013 24th Micromechanics and Microsystems Europe Conference
Available from: 2013-12-11 Created: 2013-12-11 Last updated: 2014-02-03Bibliographically approved

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Hjort, KarinHjort, KlasSandegren, LinusWu, Zhigang

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Hjort, KarinHjort, KlasSandegren, LinusWu, Zhigang
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Microsystems TechnologyDepartment of Medical Biochemistry and Microbiology
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