Intake and serum concentrations of α-tocopherol in relation to fractures in elderly women and men: 2 cohort studies
2014 (English)In: American Journal of Clinical Nutrition, ISSN 0002-9165, E-ISSN 1938-3207, Vol. 99, no 1, 107-114 p.Article in journal (Refereed) Published
A reduction in the formation of free radicals and oxidative stress might reduce the rate of bone loss and muscle wasting.
The objective was to determine whether α-tocopherol intake or serum concentrations are associated with fracture risk in older women and men.
Two cohort studies, the Swedish Mammography Cohort (SMC; n = 61,433 women) and the Uppsala Longitudinal Study of Adult Men (ULSAM; n = 1138 men), were used.
During 19 y of follow-up, 14,738 women in the SMC experienced a first fracture at any site (3871 hip fractures). A higher hip fracture rate was observed with lower intakes of α-tocopherol. Compared with the highest quintile of intake, the lowest quintile had a multivariable-adjusted HR of 1.86 (95% CI: 1.67, 2.06). The HR of any fracture was 1.20 (95% CI: 1.14, 1.28). α-Tocopherol-containing supplement use was associated with a reduced rate of hip fracture (HR: 0.78; 95% CI: 0.65, 0.93) and any fracture (HR: 0.86; 95% CI: 0.78, 0.94). Compared with the highest quintile of α-tocopherol intake in ULSAM (follow-up: 12 y), lower intakes (quintiles 1-4) were associated with a higher rate of hip fracture (HR: 3.33; 95% CI: 1.43, 7.76) and any fracture (HR: 1.84; 95% CI: 1.18, 2.88). The HR for hip fracture in men for each 1-SD decrease in serum α-tocopherol was 1.58 (95% CI: 1.13, 2.22) and for any fracture was 1.23 (95% CI: 1.02, 1.48).
Low intakes and low serum concentrations of α-tocopherol are associated with an increased rate of fracture in elderly women and men.
Place, publisher, year, edition, pages
2014. Vol. 99, no 1, 107-114 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-212497DOI: 10.3945/ajcn.113.064691ISI: 000329080200014PubMedID: 24225359OAI: oai:DiVA.org:uu-212497DiVA: diva2:678076