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Intake and serum concentrations of α-tocopherol in relation to fractures in elderly women and men: 2 cohort studies
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics.
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2014 (English)In: American Journal of Clinical Nutrition, ISSN 0002-9165, E-ISSN 1938-3207, Vol. 99, no 1, 107-114 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND:

A reduction in the formation of free radicals and oxidative stress might reduce the rate of bone loss and muscle wasting.

OBJECTIVE:

The objective was to determine whether α-tocopherol intake or serum concentrations are associated with fracture risk in older women and men.

DESIGN:

Two cohort studies, the Swedish Mammography Cohort (SMC; n = 61,433 women) and the Uppsala Longitudinal Study of Adult Men (ULSAM; n = 1138 men), were used.

RESULTS:

During 19 y of follow-up, 14,738 women in the SMC experienced a first fracture at any site (3871 hip fractures). A higher hip fracture rate was observed with lower intakes of α-tocopherol. Compared with the highest quintile of intake, the lowest quintile had a multivariable-adjusted HR of 1.86 (95% CI: 1.67, 2.06). The HR of any fracture was 1.20 (95% CI: 1.14, 1.28). α-Tocopherol-containing supplement use was associated with a reduced rate of hip fracture (HR: 0.78; 95% CI: 0.65, 0.93) and any fracture (HR: 0.86; 95% CI: 0.78, 0.94). Compared with the highest quintile of α-tocopherol intake in ULSAM (follow-up: 12 y), lower intakes (quintiles 1-4) were associated with a higher rate of hip fracture (HR: 3.33; 95% CI: 1.43, 7.76) and any fracture (HR: 1.84; 95% CI: 1.18, 2.88). The HR for hip fracture in men for each 1-SD decrease in serum α-tocopherol was 1.58 (95% CI: 1.13, 2.22) and for any fracture was 1.23 (95% CI: 1.02, 1.48).

CONCLUSION:

Low intakes and low serum concentrations of α-tocopherol are associated with an increased rate of fracture in elderly women and men.

Place, publisher, year, edition, pages
2014. Vol. 99, no 1, 107-114 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-212497DOI: 10.3945/ajcn.113.064691ISI: 000329080200014PubMedID: 24225359OAI: oai:DiVA.org:uu-212497DiVA: diva2:678076
Available from: 2013-12-11 Created: 2013-12-11 Last updated: 2017-12-06Bibliographically approved

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Michaëlsson, KarlByberg, LiisaÄrnlöv, JohanMelhus, Håkan

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