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Macrocylic inhibitors of hepatitis C virus
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2012 (English)Patent (Other (popular science, discussion, etc.))
Abstract [en]

Inhibitors of HCV replication of formula (I)

and the N-oxides, salts, and stereoisomers, wherein

  • each dashed line represents an optional double bond;
  • X is N, CH and where X bears a double bond it is C;
  • R1 is —OR7, —NH—SO2R8;
  • R2 is hydrogen, and where X is C or CH, R2 may also be C1-6alkyl;
  • R3 is hydrogen, C1-6alkyl, C1-6alkoxyC1-6alkyl, C3-7cycloalkyl;
  • R4 is aryl or Het; n is 3, 4, 5, or 6;
  • R5 is halo, C1-6alkyl, hydroxy, C1-6alkoxy, phenyl, or Het;
  • R6 is C1-6alkoxy, or dimethylamino;
  • R7 is hydrogen; aryl; Het; C3-7cycloalkyl optionally substituted with C1-6alkyl; or C1-6alkyl optionally substituted with C3-7cycloalkyl, aryl or with Het;
  • R8 is aryl; Het; C3-7cycloalkyl optionally substituted with C1-6alkyl; or C1-6alkyl optionally substituted with C3-7cycloalkyl, aryl or with Het;
  • aryl is phenyl optionally substituted with one, two or three substituents;
  • Het is a 5 or 6 membered saturated, partially unsaturated or completely unsaturated heterocyclic ring containing 1 to 4 heteroatoms selected from nitrogen, oxygen and sulfur, and being optionally substituted with one, two or three substituents;
  • pharmaceutical compositions containing compounds (I) and processes for preparing compounds (I). Bioavailable combinations of the inhibitors of HCV of formula (I) with ritonavir are also provided.
Place, publisher, year, edition, pages
2012.
National Category
Medicinal Chemistry
Research subject
Medicinal Chemistry
Identifiers
URN: urn:nbn:se:uu:diva-212549OAI: oai:DiVA.org:uu-212549DiVA: diva2:678289
Patent
US Patent 8349869
Available from: 2013-12-11 Created: 2013-12-11 Last updated: 2013-12-11

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Belfrage,, Anna Karin G. L.

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