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CYSTEINE PROTEASE INHIBITORS
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2011 (English)Patent (Other (popular science, discussion, etc.))
Abstract [en]

Compounds of the formula I

wherein

R1a is H; and R1b is C1-C6 alkyl, Carbocyclyl or Het; or

R1a and R1b together define a saturated cyclic amine with 3-6 ring atoms;

R2a and R2b are H, halo, C1-C4alkyl, C1-C4haloalkyl, C1-C4alkoxy; or

R2a and R2b together with the carbon atom to which they are attached form a C3-C6cycloalkyl;

R3 is a branched C5-C10alkyl chain, C2-C4haloalkyl or C3-C7cycloalkylmethyl,

R4 is Het, Carbocyclyl,

optionally substituted as defined in the specification and pharmaceutically acceptable salts,

hydrates and N-oxides thereof; are inhibitors of cathepsin S and have utility in the treatment of psoriasis, autoimmune disorders and other disorders such as asthma, arteriosclerosis, COPD and chronic pain.

Place, publisher, year, edition, pages
2011.
National Category
Medicinal Chemistry
Research subject
Medicinal Chemistry
Identifiers
URN: urn:nbn:se:uu:diva-212554OAI: oai:DiVA.org:uu-212554DiVA: diva2:678300
Patent
US Patent App.20110312964
Available from: 2013-12-11 Created: 2013-12-11 Last updated: 2018-01-11

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Belfrage, Anna Karin

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