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Fluorogenic probes using 4-substituted-2-nitrobenzenesulfonyl derivatives as caging groups for the analysis of human glutathione transferase catalyzed reactions
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2013 (English)In: The Analyst, ISSN 0003-2654, E-ISSN 1364-5528, Vol. 138, no 24, 7326-7330 p.Article in journal (Refereed) Published
Abstract [en]

We have synthesized a series of 4-substituted-2-nitrobenzene-sulfonyl compounds for caged fluorogenic probes and conducted a Hammett plot analysis using the steady-state kinetic parameters. The results revealed that the glutathione transferase (GST) alpha catalyzed reaction was dependent on the sigma value in the same way as the non-enzymatic reaction, whereas the dependence of the sigma value of the GST mu and pi was not as pronounced as that of GST alpha.

Place, publisher, year, edition, pages
2013. Vol. 138, no 24, 7326-7330 p.
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Natural Sciences
URN: urn:nbn:se:uu:diva-213096DOI: 10.1039/c3an01339aISI: 000326988500009OAI: oai:DiVA.org:uu-213096DiVA: diva2:681216
Available from: 2013-12-19 Created: 2013-12-18 Last updated: 2013-12-19Bibliographically approved

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Mannervik, Bengt
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