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Low cellular IRS 1 gene and protein expression predict insulin resistance and NIDDM.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Endocrinology, Diabetes and Metabolism.
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1999 (English)In: The FASEB Journal, ISSN 0892-6638, E-ISSN 1530-6860, Vol. 13, no 15, 2173-8 p.Article in journal (Refereed) Published
Abstract [en]

We examined the gene and protein expression of IRS 1 (insulin receptor substrate 1) in adipocytes from two groups of healthy individuals with an increased propensity for non-insulin-dependent diabetes mellitus (NIDDM): those with two first-degree relatives with diabetes and another group with massive obesity. A low expression of IRS 1 (</=50% of the matched control group) was seen in approximately 30% of both groups and these individuals were characterized by insulin resistance and its hallmarks: higher levels of insulin, glucose, and triglycerides. Two individuals with previously unknown NIDDM were diagnosed and both had low IRS 1 expression. Low IRS 1 protein expression was associated with low mRNA levels but not with the common Gly972Arg polymorphism of the IRS 1 gene. Taken together, our present and previous findings show that a low expression of IRS 1 in fat cells predicts insulin resistance and NIDDM. Furthermore, they support the likelihood that an impaired transcriptional activation may play a key role in the pathogenesis of NIDDM.-Carvalho, E., Jansson, P.-A., Axelsen, M., Eriksson, J. W., Huang, X., Groop, L., Rondinone, C., Sjöström, L., Smith, U. Low cellular IRS 1 gene and protein expression predict insulin resistance and NIDDM.

Place, publisher, year, edition, pages
1999. Vol. 13, no 15, 2173-8 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-211317PubMedID: 10593864OAI: oai:DiVA.org:uu-211317DiVA: diva2:681546
Available from: 2013-12-20 Created: 2013-11-21 Last updated: 2013-12-20

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