Increased lactate release per fat cell in normoglycemic first-degree relatives of individuals with type 2 diabetes.
2001 (English)In: Diabetes, ISSN 0012-1797, E-ISSN 1939-327X, Vol. 50, no 10, 2344-8 p.Article in journal (Refereed) Published
The aim of this study was to examine subcutaneous lactate production in the relatives of individuals with type 2 diabetes. Therefore, we recruited seven healthy first-degree relatives of type 2 diabetic patients and seven pairwise, matched, healthy control subjects without any heredity for diabetes. All subjects were studied with a euglycemic insulin clamp at approximately 600 pmol/l, abdominal subcutaneous microdialysis, and (133)Xe clearance. Furthermore, a subcutaneous needle biopsy was performed to determine fat cell size. In the fasting state, interstitial lactate was 40% higher in relatives than in control subjects (P = 0.043), but net lactate production was similar in both groups. However, during the insulin clamp, interstitial lactate (2.50 +/- 0.29 vs. 1.98 +/- 0.26 mmol/l, P = 0.018), interstitial-arterial lactate concentration difference (1.08 +/- 0.30 vs. 0.53 +/- 0.24 mmol/l, P = 0.028), and net lactate release per fat cell (10.9 +/- 3.7 vs. 2.8 +/- 1.3 fmol. cell(-1). min(-1), P = 0.018) were increased in the relatives. We conclude that first-degree relatives of type 2 diabetic patients may have an enhanced net lactate release per fat cell in abdominal subcutaneous tissue. This could suggest a pathological regulation in adipose tissue that is of importance for the metabolic defects known in type 2 diabetic relatives.
Place, publisher, year, edition, pages
2001. Vol. 50, no 10, 2344-8 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-211313PubMedID: 11574418OAI: oai:DiVA.org:uu-211313DiVA: diva2:681551