uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Food deprivation increases post-heparin lipoprotein lipase activity in humans.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Endocrinology, Diabetes and Metabolism.
Show others and affiliations
2001 (English)In: European Journal of Clinical Investigation, ISSN 0014-2972, E-ISSN 1365-2362, Vol. 31, no 12, 1040-7 p.Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: To study the effect of fasting on lipoprotein lipase (LPL) activity in human post-heparin plasma, representing the functional pool of LPL.

DESIGN: Fourteen healthy volunteers were recruited for the study. The subjects were fasted for 30 h. Activities of LPL and hepatic lipase (HL), and LPL mass, were measured in pre- and post-heparin plasma in the fed and in the fasted states, respectively. For comparison, LPL and HL activities were measured in pre- and post-heparin plasma from fed and 24-h-fasted guinea pigs.

RESULTS: Fasting caused a significant drop in the levels of serum insulin, triglycerides and glucose in the human subjects. Post-heparin LPL activity increased from 79 +/- 6.4 mU mL-1 in the fed state to 112 +/- 10 mU mL-1 in the fasted state (P < 0.01), while LPL mass was 361 +/- 29 in the fed state and 383 +/- 28 in the fasted state, respectively (P = 0.6). In contrast, fasting of guinea pigs caused an 80% drop in post-heparin LPL activity. The effect of fasting on human and guinea pig post-heparin HL activity were moderate and statistically not significant.

CONCLUSIONS: In animal models such as rats and guinea pigs, post-heparin LPL activity decreases on fasting, presumably due to down-regulation of adipose tissue LPL. In humans, fasting caused increased post-heparin LPL activity.

Place, publisher, year, edition, pages
2001. Vol. 31, no 12, 1040-7 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-211309PubMedID: 11903489OAI: oai:DiVA.org:uu-211309DiVA: diva2:681559
Available from: 2013-12-20 Created: 2013-11-21 Last updated: 2013-12-20

Open Access in DiVA

No full text

By organisation
Endocrinology, Diabetes and Metabolism
In the same journal
European Journal of Clinical Investigation
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 163 hits
ReferencesLink to record
Permanent link

Direct link