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Breaking and building the wall: the biology of the blood-brain barrier in health and disease
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Cancer and Vascular Biology.
2013 (English)In: Swiss Medical Weekly, ISSN 1424-7860, E-ISSN 1424-3997, Vol. 143, UNSP w13892- p.Article, review/survey (Refereed) Published
Abstract [en]

The blood-brain barrier (BBB) is a complex feature of brain endothelial cells that restricts the passage of bloodborne molecules into the brain parenchyma, while ensuring the delivery of essential nutrients and selected biomolecules. Brain vasculature is anatomically distinct from that of other organs and comprises in addition to endothelial cells, pericytes and astrocytes, which collectively form the neurovascular unit (NVU). This review focuses on the regulation of BBB properties by the NVU and the periphery. A brief overview of cellular components of the NVU, and BBB characteristics will be provided, with more emphasis placed on the molecular mechanisms involved in the development of brain vasculature and human genetic diseases primarily affected by dysfunction of components of the NVU. In addition, the regulation of brain vasculature by peripheral factors such as diet and systemic disease is discussed.

Place, publisher, year, edition, pages
2013. Vol. 143, UNSP w13892- p.
Keyword [en]
blood-brain barrier, neurovascular unit, endothelium, pericytes, astrocytes, brain pathology
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-213315DOI: 10.4414/smw.2013.13892ISI: 000326940000006OAI: oai:DiVA.org:uu-213315DiVA: diva2:682155
Available from: 2013-12-23 Created: 2013-12-20 Last updated: 2013-12-23Bibliographically approved

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