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Prognostic implications of changes in cardiac troponin I levels in patients with non-ST elevation acute coronary syndrome
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology.
2013 (English)In: Biomarkers, ISSN 1354-750X, E-ISSN 1366-5804, Vol. 18, no 8, 668-672 p.Article in journal (Refereed) Published
Abstract [en]

Objective: Information is limited on the prognostic implications of cardiac troponin I (cTnI) changes during the first days of non-ST elevation acute coronary syndrome (NSTE-ACS). Methods: High-sensitivity cTnI levels were measured at study inclusion and after 48 h in 1615 conservatively managed NSTE-ACS patients from the Global Use of Strategies To Open Occluded Coronary Arteries (GUSTO) IV trial. Results: Patients with moderately increased cTnI levels and without a relevant decrease over time had a significantly raised mortality at 30 days and 1 year. No relevant associations between cTnI changes and recurrent myocardial infarction were seen. Conclusion: The cTnI change is predictive for subsequent mortality in selected conservatively managed NSTE-ACS patients.

Place, publisher, year, edition, pages
2013. Vol. 18, no 8, 668-672 p.
Keyword [en]
Acute coronary syndrome, cardiac troponin I, cardiovascular events, risk prediction
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Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-213458DOI: 10.3109/1354750X.2013.843023ISI: 000327504100005OAI: oai:DiVA.org:uu-213458DiVA: diva2:682717
Available from: 2013-12-30 Created: 2013-12-23 Last updated: 2017-12-06Bibliographically approved

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Eggers, Kai M.James, StefanVenge, PerLindahl, Bertil

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