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Spatial analysis of diffusion tensor tractography statistics along the inferior fronto-occipital fasciculus with application in progressive supranuclear palsy
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Radiology.
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2013 (English)In: Magnetic Resonance Materials in Physics, Biology and Medicine, ISSN 0968-5243, E-ISSN 1352-8661, Vol. 26, no 6, 527-537 p.Article in journal (Refereed) Published
Abstract [en]

The purpose of the study was to develop a method for analysis of diffusion parameters along white matter (WM) tracts, using spatial normalization based on anatomical landmarks, and to introduce the apparent area coefficient (AAC). The method's applicability was tested in the inferior fronto-occipital fasciculus (IFO) in patients with progressive supranuclear palsy (PSP) and healthy controls (HCs). A framework for analysis of diffusion parameters was developed. Spatial normalization of the tracts was performed using anatomical landmarks, to avoid deformations caused by cerebral atrophy. Initially, 38 HCs were used to optimize a threshold for the minimal size of regions that differ between groups. The fractional anisotropy, mean diffusivity, AAC, and the hemispheric asymmetry index (AI), were compared between 11 PSP patients and 15 HCs. The method was feasible for analysis of PSP patients and HCs. The AI showed that the observed hemispheric asymmetry of AAC was significantly larger in PSP patients compared with HCs in small regions of the IFO. The method was successfully employed for analysis of diffusion parameters along the IFO in a patient group. This method can be potentially useful in studies of WM diseases, with or without cerebral atrophy.

Place, publisher, year, edition, pages
2013. Vol. 26, no 6, 527-537 p.
Keyword [en]
DTI, Tractography, Inferior fronto-occipital fasciculus, PSP
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-213480DOI: 10.1007/s10334-013-0368-5ISI: 000327438700003OAI: oai:DiVA.org:uu-213480DiVA: diva2:682895
Available from: 2013-12-30 Created: 2013-12-23 Last updated: 2017-12-06Bibliographically approved
In thesis
1. Diffusion tensor magnetic resonance imaging of the brain: Tractography analysis with application in healthy individuals and patients
Open this publication in new window or tab >>Diffusion tensor magnetic resonance imaging of the brain: Tractography analysis with application in healthy individuals and patients
2017 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

In study 1, thirty-eight healthy controls were used for optimization of the method. Fifteen patients with progressive supranuclear palsy and an equal number of age-matched healthy controls underwent diffusion tensor MRI and were then investigated and compared groupwise.

It was shown that tractography analyses may preferably be performed regionally, such as along the tracts or in different segments of the tracts. Normalization of white matter tracts can be performed using anatomical landmarks.

In study 2, 104 males and 153 females in the age interval 13 to 84 years of age participated as healthy individuals in order to investigate age-related changes with diffusion tensor MRI.

It was shown that spatially differences in age-related changes exist between subdivided segments within white matter tracts. The aging processes within the CB and the IFO vary regionally.

In study 3, 38 human brains were used for investigation of the white matter tract inferior longitudinal fasciculus (ILF) and its subcomponents. Of these, white matter anatomical dissection was performed in 14 post-mortem normal human brains. The remaining 24 brains were investigated in vivo with diffusion tensor MRI in healthy individuals.

It was validated that fibers of the ILF in the occipito-temporal region have a clear, constant and detailed organisation. The anatomical connectivity pattern, and quantitative differences between the ILF subcomponents, confirmed a pivotal role of the ILF.

In study 4, 12 patients with iNPH were included in the study and examined with diffusion tensor at three time points. For comparison, 12 healthy controls, matched by gender and age were also included. Controls were examined with MRI only once.

It was shown that DTI measures differ significantly between patients with iNPH and healthy controls. DTI measures of the CC, the CST and the SLF, correlated to changes in clinical symptoms after shunt surgery.

Deeper knowledge about functions of the brain increases possibilities to take advantages from DTI analyses with tractography. 

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2017. 62 p.
Series
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ISSN 1651-6206 ; 1394
Keyword
Magnetic Resonance Imaging, Diffusion Tensor Imaging, Tractography, white matter tracts
National Category
Radiology, Nuclear Medicine and Medical Imaging
Research subject
Radiology
Identifiers
urn:nbn:se:uu:diva-332596 (URN)978-91-513-0147-1 (ISBN)
Public defence
2017-12-20, Gustavianum, Auditorium Minus, Akademigatan 3, Uppsala, 09:15 (English)
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Available from: 2017-11-29 Created: 2017-10-30 Last updated: 2017-11-29

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Mårtensson, JohannaLarsson, Elna-Marie

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