uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Genetic polymorphisms in monoamine systems and outcome of cognitive behavior therapy for social anxiety disorder
Show others and affiliations
2013 (English)In: PLoS ONE, ISSN 1932-6203, Vol. 8, no 11, e79015- p.Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: The role of genetics for predicting the response to cognitive behavior therapy (CBT) for social anxiety disorder (SAD) has only been studied in one previous investigation. The serotonin transporter (5-HTTLPR), the catechol-o-methyltransferase (COMT) val158met, and the tryptophan hydroxylase-2 (TPH2) G-703Tpolymorphisms are implicated in the regulation of amygdala reactivity and fear extinction and therefore might be of relevance for CBT outcome. The aim of the present study was to investigate if these three gene variants predicted response to CBT in a large sample of SAD patients.

METHOD: Participants were recruited from two separate randomized controlled CBT trials (trial 1: n = 112, trial 2: n = 202). Genotyping were performed on DNA extracted from blood or saliva samples. Effects were analyzed at follow-up (6 or 12 months after treatment) for both groups and for each group separately at post-treatment. The main outcome measure was the Liebowitz Social Anxiety Scale Self-Report.

RESULTS: At long-term follow-up, there was no effect of any genotype, or gene × gene interactions, on treatment response. In the subsamples, there was time by genotype interaction effects indicating an influence of the TPH2 G-703T-polymorphism on CBT short-term response, however the direction of the effect was not consistent across trials.

CONCLUSIONS: None of the three gene variants, 5-HTTLPR, COMTval158met and TPH2 G-703T, was associated with long-term response to CBT for SAD.

Place, publisher, year, edition, pages
2013. Vol. 8, no 11, e79015- p.
National Category
Social Sciences
URN: urn:nbn:se:uu:diva-213684DOI: 10.1371/journal.pone.0079015ISI: 000327258600014PubMedID: 24260145OAI: oai:DiVA.org:uu-213684DiVA: diva2:683158
Swedish Research Council
Available from: 2014-01-02 Created: 2014-01-02 Last updated: 2014-01-17Bibliographically approved

Open Access in DiVA

fulltext(235 kB)122 downloads
File information
File name FULLTEXT01.pdfFile size 235 kBChecksum SHA-512
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Furmark, Tomas
By organisation
Department of Psychology
In the same journal
Social Sciences

Search outside of DiVA

GoogleGoogle Scholar
Total: 122 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 217 hits
ReferencesLink to record
Permanent link

Direct link